Takeda Pharmaceutical Company Limited

Altana Pharma Ag

Wolfgang Ise

Wolfram Steinhilber

Henning Gieseler

Markus Rast

Peter Skufca

Gerhard Becker

R&uuml;diger Nave

Reinhold Schmidt

Andreas G&uuml;nther

Jurgen Volz

The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.

Formulation of an antibody and use thereof

Methods for determining the strongly hydrophobic pulmonary surfactant protein SP-C, SP-C specific antibody and a reagent kit for carrying out the methods are described.

Determination of the hydrophobic pulmonary surfactant protein SP-C

This-layer chromatography is used to separate, identify and quantity hydrophobic protein, hydrophobic protein fragment, hydrophobic modified protein and hydrophobic peptide. A method is thus provided for determination of proteins and peptides which, due to their low solubility in an aqueous solvent system, cannot be determined by conventional methods, such as ELISA, which are based on aqueous solvent systems.

Process for separating and analyzing hydrophobic proteins using thin layer chromatography

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Constance, Germany

Wolfgang Ise