Fresenius Medical Care Deutschland Gmbh

Wolfgang Hofmann

Massimo Earl Fini

Wolfgang Wehmeyer

Alain Veneroni

Jutta Passlick-Deetjen

Sonja Steppan

Kristina Gundlach

Jasmin Yillah

Janine BÜCHEL

Hans-Jürgen Arens

The invention relates to an insert and a vial for the infusion of a liquid. The vial comprises a hollow body, a grasp portion and a head. The head comprises a delivery opening defining an axis X; a septum for closing the opening; and at least one circumferential push surface next to the head and firmly connected to the grasp portion. The insert is suitable to deliver the liquid and to receive the vial along axis X. The insert comprises a main body with lower ducts, an inner part and a piercing spike. The inner part defines a seat for the vial head, and comprises one slit for engaging the circumferential push surface. The spike is suitable to pierce the vial septum and defines upper ducts. The inner part is able to rotate inside the main body between a fluidly open configuration and a fluidly closed configuration.

Insert and vial for the infusion of liquids

The invention relates to a device and a method for depletion of hepcidin from blood for treatment of iron deficiency, in particular in anemic patients suffering from chronic renal failure, with the goal of increasing the availability of iron in the body and thus improving the treatment of the anemia. The hepcidin adsorbent comprises a matrix and a hepcidin-binding ligand covalently bonded to the matrix with an affinity having a dissociation constant KD of less than 200 nM.

Adsorbents for the adsorption of hepcidin

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Frankfurt-am-Main, Germany

Wolfgang Hofmann