Riedel-De Haen Aktiengesellschaft

Wolfgang Hirsch

In the process for the production of a diagnostic agent for the detection of ketones, consisting of an absorbent carrier impregnated in a first stage with an aqueous solution of an amino acid and tetrasodium ethylenediamine tetraacetate as buffer, dried and impregnated in a second stage with a solution of sodium nitroferricyanide in a solvent mixture one component of which is methanol and dried again, the improvement which comprises using as the second component of the solvent mixture, instead of dimethyl formamide, which is considered detrimental to health, quite a number of other solvents.

Process for the production of a diagnostic agent for the detection of

4-Fluoro-3-nitrobenzenediazonium salts in test compositions capable of specific and sensitive determination of urobilinogen without any interference of bilirubin in an aqueous solution or body fluid such as urine. The diazonium salts have incorporated special stabilizing anions. In addition to a 4-fluoro-3-nitrobenzene diazonium salt, the test compositions preferably include an acid constituent capable of producing an acid pH upon contacting the solution to be tested. The test device comprises a bibulous carrier member, such as paper impregnated with the test composition in dry form.

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Luthe, Germany

Wolfgang Hirsch