Gruenenthal Gmbh

Grunenthal Gmbh

Wolfgang Hell

Markus Kegel

Helmut Heinrich Buschmann

Oswald K Zimmer

Helmut Buschmann

Joerg Holenz

Michael Gruss

Detlef Heller

Stefan Gladow

Felix Spindler

Andreas Fischer

Markus Von Raumer

Hans-Joachim Drexler

Joerg Berghausen

Martin Szelagiewicz

Susan Margaret De Paul

Irene Vaulont

Stefan Pruehs

Jörg Berghausen

Carsten Griebel

Hartmut Loebermann

Bernhard Akteries

Urs Siegrist

Olaf Schaefer

Anita Schnyder

Jörg Holenz

Harmut Loebermann

Jorg Holenz

Lars Pumpenmeier

Alfed Olbrich

Robert Hett

Emad El Sayed

Dieter Haag

Susan Margaret Paul

Hans-Joachin Drexler

Helmut Heinrich Buschhmann

Stefan Prühs

Olaf SCHÄFER

The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.

Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.

Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol

Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of Rand Ris not a hydrogen atom and the diphosphine ligand is chiral.

Process for preparing a substituted dimethyl-(3-arylbutyl)amine compound by homogeneous catalysis

A process for the preparation of (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano[3,4b]indol]-4-amine and (1r,4r)-6&#x2032;-fluoro-N-methyl-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano[3,4b]-indol]-4-amine or physiologically acceptable acid addition salts thereof.

Process for the preparation of (1r,4r)-6'-fluoro-(N,N-dimethyl- and N-methyl)-4-phenyl-4&#x2032;,9&#x2032;-dihydro-3&#x2032;H-spiro[cyclohexane-1,1&#x2032;-pyrano-[3,4,b]indol]-4-amine

This invention relates to solid crystalline forms of (1RS,3RS,6RS)-6-Dimethylaminomethyl-1-(3-methoxy-phenyl)cyclohexane-1,3-diol hydrochloride (1), methods of producing 1, methods of use of 1, use of 1 as analgesics and pharmaceutical compositions comprising 1.

Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride

The present invention relates to an improved process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.

[object Object]

A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compositions containing the various crystalline forms of this salt, and the use of this salt as a pharmacologically active agent in a pharmaceutical composition to treat or inhibit pain or other disorders or disease states.

HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol

Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.

Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof

A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C-Calkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C-Calkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.

Process for producing 6-dimethylaminomethyl-phenyl-cyclohexane-1,3-diols

A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.

Process for producing (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol

The invention concerns a method for the isolation of a stereoisomer from a mixture comprising the two stereoisomers of the general formulae (I-A) and (I-A') and/or the two stereoisomers of the general formulae (I-B) and (I-B&#x2032;) 

Separation of stereoisomeric N,N-dialkylamino-2alkyl-3-hydroxy-3-phenylalkanes

Methods for the dehydration of substituted 1-amino-3-aryl-butan-3-ol compounds for the preparation of substituted 3-aryl-butyl-amine compounds.

Process for the preparation of substituted 3-aryl-butylamine compounds

The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.

Process for chlorinating tertiary alcohols

The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol as a saccharinate from a mixture of the diastereomers (1SR,2)RS-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and (1SR-2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol and optionally impurities.

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Aachen, Germany

Wolfgang Hell