Other

Genetrix B.v.

Wolfgang Fritzsche

Karsten Koenig

Johann Michael Köhler

Johann Michael Koehler

Frederik Schut

Andrea Czaki

Paris Som Tjwan Tan

Antje Wiegand

Louis Oosting

The invention relates to a method for the simultaneous dissection in specific positions of filiform organic molecular chains, in particular DNA. The aim of the invention is to provided a method, by which a highly specific dissection can take place on certain sequences that can be freely selected and simultaneously on numerous filiform molecules. To achieve this, nanoparticles () are provided with a molecular chain () of any predeterminable sequence, which is selected to be complementary to a sequence of a molecule () that is to be dissected, said molecular chain(s) () is/are hybridised in the usual manner with the molecule, or specifically linked to said molecule in another manner and the nanoparticles () are subsequently subjected to a high-energy radiation of at least one wavelength, which can be absorbed by said nanoparticles ().

Method for the simultaneous dissection in specific positions of filiform organic molecular chains, in particular DNA

The invention relates to an affinity sensor for detecting specific molecular binding events, for use in the field of molecular biology, e.g., in medical diagnostics, especially in biosensor technology or in DNA microarreay tests. The aim of the invention is to provide an affinity sensor of this type for rapidity, sensitively, specifically, economically and routinely detecting the presence of molecules, especially bioactive molecules, and to provide special applications for an affinity sensor of this type. To this end, the affinity sensor consists of a support substrate which is provided with at least two electrodes. The electrodes are situated equidistantly from each other and cover an area on both sides, at least this area being provided for receiving immobilized specific binding partners which are capable of coupling complementary corresponding binding partners directly or with other specific binding molecules. The area is established with a minimum width b, in such a way that at least one complementary corresponding binding partner which is provided with an electroconductive particle can be received in the area in such a way as to guarantee the possibility of a tunnel-type contact junction forming between the particle and the electrodes in each case. The affinity sensor is used for biomonitoring.

Affinity sensor for detecting specific molecular binding events and use thereof

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Jena, Germany

Wolfgang Fritzsche