Other

Boehringer Ingelheim Pharma Gmbh & Co Kg

Scil Technology Gmbh

Hoffmann-la Roche Inc.

Wyeth

Freie Universitat Berlin

Veyx-pharma Gmbh

University of Erlangen-nurnberg

Henkel Ag & Company, Kgaa

Wolfgang Friess

Patrick Garidel

Torsten Schultz-Fademrecht

Karoline Bechtold-Peters

Stefan Bassarab

Richard Fuhrherr

Michael Wiggenhorn

Cornelius Pompe

Klaus Hellerbrand

Michael Siedler

Andreas Schuetz

Samuel Herberg

Manfred Resch

Manfred Fries

Hanns-Christian Mahler

Rainer Haag

Marie Weinhart

Wolfgang Zaremba

Yordanka Yordanova

Uwe Schedler

Astrid Pappenberger

Sylvia Kiese

Daniel Schwartz

Tobias Becherer

Madeleine Witting

Sarah Küchler

Dirk Steinhilber

Johannes Kauffold

Kerstin Hoffmann

Susan J Sofia

Martina Raus

Henriette Bendz

August Bernd

Conrelius Pompe

Karsten Rüdiger Mewes

Sarah Hedtrich

Kerstin HÖGER

Stefan Kippenberger

Andreas SCHÜTZ

A veterinary pharmaceutical composition, including at least one active veterinary pharmaceutical substance which is selected among gonadorelin and gonadorelin analogs as well as salts of gonadorelin and of the gonadorelin analogs, is provided. The composition includes a liposome-free matrix which delays the release of the active veterinary pharmaceutical substance from the composition, which matrix includes a basic material which is selected from the group consisting of natural and synthetic triglycerides, vegetable oils, diacylpropanediols, diacylbutanediols and mixtures of these substances, the veterinary pharmaceutical composition including no biodegradable polymer.

Veterinary pharmaceutical composition and use thereof

A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances.

Method for producing a polyglycerol nanogel for the encapsulation and release of biologically active substances

The invention provides a monitoring device () for a dryer () includes a means for sensing a physical parameter, such as temperature or strain, at a sensing locus within the dryer (), for example at a vial (). The sensing means comprises an optical sensing fiber () having at least one fiber Bragg grating (). Moreover, the invention provides a dryer, in particular a freeze dryer (), which is equipped with such monitoring device ().

Dryer with monitoring device

The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.

Biomaterial containing degradation stabilized polymer

The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.

Disclosed are methods of making BMP-2 microparticles and methods of using the microparticles. These microparticles are prepared, for example, by mixing a solution containing BMP-2 with a second solution whose ionic concentration and pH results in the precipitation of the BMP-2.

Formulation comprising bioactive agents and method of using same

The invention relates to a method for stabilizing an aqueous protein solution against exogenous stress and to the use of a container for stabilizing an aqueous protein solution.

Method for stabilizing a protein

The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.

Powder comprising new compositions of oligosaccharides and methods for their preparation

The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.

Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation

Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody derivatives as pharmaceutical active substance. The production of powders is accomplished through spray drying or freeze drying. Also disclosed are the corresponding antibody-containing powders as well as processes for their production.

1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives

A flat carrier having a power supply, for example in the form of a coil. The carrier is characterized by an electroluminescent device that contains two flat electrodes lying above one another and an electroluminescent paste located between the electrodes. The electrodes of the electroluminescent device are connected to terminals of the power supply, which can be implemented, for example, as a coil or battery.

Flat carrier with an indicating device

An arrangement for storing and displaying coins and the like includes a rigid mounting device having one or more openings for receiving a coin, the coin being mounted in the opening such that both sides of the coin may be viewed, the mounting means having coin-engaging portions which are made of a material which does not adversely affect the coin.

System for the storage of coins and the like

Growing community of inventors

Iffeldorf, Germany

Wolfgang Friess