Bayer Aktiengesellschaft

Wolfgang Dummer

Klaus Grohe

Arnold Paessens

Kai Rossen

Gerhard Darsow

Wilfried Niemeier

In a process for producing aliphatic .alpha.,.omega.-diols comprising 4 to 12 C atoms from aliphatic .alpha.,.omega.-dicarboxylic acids comprising 4 to 12 C atoms, an oligoester of average chain length n=3 to n=4.5 and with an acid number of 40 to 60 mg KOH/g reaction mixture is first formed from a diol and a dicarboxylic acid, which oligoester is thereafter catalytically hydrogenated in the liquid phase. Hydrogenation is carried out continuously at 180 to 250.degree. C. and at an H.sub.2 pressure of 100 to 400 bar, over a pelletised catalyst which is free from Zn oxide and which comprises pressed powders of Cu, Mn and Al oxides with a content of at least one oxide of metals of subgroup VI of the periodic table of the elements (Mendeleev). The amount of H.sub.2 is 20 to 100 times the amount required stoichiometrically.

Process for producing aliphatic diols

New quinolone-carboxylic acids of the general formula (I) ##STR1## wherein the definitions for R.sub.1 -R.sub.9 are given in the description, a process for their preparation and their use as medicaments, in particular as antiviral agents.

Quinolonecarboxylic acid derivatives

Quinolonecarboxylic acid derivatives and their use as antiviral agents

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Colonge, Germany

Wolfgang Dummer