Wisconsin Alumni Research Foundation

Koninklijke Philips Corporation N.v.

Montefiore Medical Center

Wolfgang Axel Tomé

Thomas Rockwell Mackie

Jamey Paul Weichert

Anatoly Pinchuk

Edward Bender

Nicholas Gordon Lance Hardcastle

Madhur Garg

Lee Goddard

Carlo Greco

Dongxu Wang

Eric Drew Ehler

A sterilizable device comprising electromagnetic transponders separated from one another by a flexible spacer material enclosed within radiofrequency-transparent sterilizable tubing for target tracking during prostate treatments, and method of use thereof.

Sterilizable fiducial beacon strand for RF target tracking

Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: or a salt thereof. Rincludes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is &#x2014;H, &#x2014;OH, &#x2014;COOH, &#x2014;COOX, &#x2014;OCOX, or &#x2014;OX, wherein X is an alkyl or an arylalkyl; Ris &#x2014;NH, &#x2014;NHZ, &#x2014;NHZ, or &#x2014;NZ, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.

Long-lived gadolinium based tumor targeted imaging and therapy agents

A method of producing a patient image indicating proton stopping power of the tissue may employ photon attenuation information converted to proton stopping power. The conversion uses different conversion functions for particular tissue types to account for a strong atomic number dependency in the conversion process. Megavoltage x-rays may be used for improved accuracy.

Method and apparatus for generating proton therapy treatment planning images

Deformation maps (e.g. deformation vector fields) used for correcting image-type data used in the treatment of patients in radiotherapy may be processed to eliminate inverse inconsistency and transitivity type errors which produce different results depending on the order or path of the calculation of deformation. The correction permits registration of a treatment plan with the changing patient image and accumulation of dose to a common reference frame without transformation dependent artifacts.

Reduction of transitivity errors in radiotherapy image registration

A virtual 4D treatment suite includes a dose calculation module, a gating module, and a dose rate adjustment module. The 4D treatment suite may be used to virtually analyze the impact the motion of a target tissue has on therapy for a particular patient and a proposed treatment plan. For example, for a proposed treatment plan, the dose calculation module may calculate a dose that would be received by a target tissue and an associated dose temporal variation based on an identified movement of the target tissue relative to at least a portion of a treatment field. Based on the calculated expected therapy dose and dose temporal variation, the gating module may determine whether to implement a gating technique for the proposed treatment plan and/or the dose rate adjustment module may determine whether to adjust the dose rate of the proposed treatment plan.

Growing community of inventors

Madison, WI, United States of America

Wolfgang Axel Tomé