Covestro Deutschland Ag

Covestro Intellectual Property Gmbh & Co. Kg

Bayer Aktiengesellschaft

Bayer Healthcare LLC

Wolf Kloeckner

Amgad Salah Moussa

Gernot Jaeger

Gernot Jäger

Thomas Hamedinger

Swantje Behnken

Guenter Olf

Franz Beggel

Volker Michele

Jens Langanke

Helmut Brod

Wolfgang Beckmann

Guido Becker

Martin Poggel

Gernot Jager

Simon Klaff

Annette Eidt

Bernd Tscheschke

Simon Klaffl

Thomas Voessing

Hasan Akyildiz

Andreas Damm

Jamaleddine Sassi

Amgad-Salah Moussa

Gernot JÄGER

Thomas VÖSSING

The invention relates to a method for producing aniline or an aniline derivative, in which a solution of aminobenzoic acid in aniline with a mass fraction of aniline in the solution, in relation to the total mass of aminobenzoic acid and aniline, in the region of 20% to 85%, is subject to a thermal decarboxylation at a temperature in the region of 165&#xb0; C. to 500&#xb0; C. without the presence of a non-system catalyst, such that the aminobenzoic acid is converted into aniline. The obtained aniline can be converted into derivatives, such as di- and polyamines of the diphenylmethane series.

Method for producing aniline or an aniline derivative

Disclosed herein is a sterilizable adapter for a cell culture vessel comprising a body, an upper connection and/or a lid, at least one port, a ventilation passage, a lower internal connection suitable for connection to a cell culture vessel and a cell retention device and/or a cell separation device as well as a device comprising said sterilizable adapter and a method for cell cultivation using said sterilizable adapter.

Adapter for cell-culture vessel

The invention relates to a method for producing aminobenzoic acid or an aminobenzoic acid derivative using a fermentation process, in which (I) the aminobenzoic acid formed in the fermentation broth obtained by the fermentation is bound in part, or as much as possible based on the solubility equilibrium, as insoluble calcium-aminobenzoate, said insoluble calcium-aminobenzoate is then (II) either isolated as such or in a mixture with the microorganism used in the fermentation and transitioned into a water soluble form, while separating an insoluble calcium salt which is different from the calcium-aminobenzoate, and then (III) by introducing carbon dioxide under pressure into the aqueous solution from the precipitated calcium salt has been released, aminobenzoic acid is precipitated.

Method for producing aminobenzoic acid or an aminobenzoic acid derivative product

The invention relates to a method for producing aminobenzoic acid or a aminobenzoic acid derivative via the fermentation of a suitable raw material under the influence of suitable microorganisms and obtaining a fermentation broth containing aminobenzoate and/or aminobenzoic acid. In particular, the invention relates to the step of obtaining the aminobenzoic acid from the fermentation broth, wherein the crystallisation of aminobenzoic acid is carried out via a simple one-stage acid treatment in the presence of seed crystals. The aminobenzoic acid crystallised in this simple manner can be easily separated from the mother liquor, further cleaned if necessary, and then supplied to the different applications.

Method for producing aminobenzoic acid or an aminobenzoic acid derivative

The present invention relates to the production of o-aminobenzoic acid from fermentable substrates using yeast cells.

Process for the production of ortho-aminobenzoic acid and/or aniline from fermentable substrate using recombinant yeast

Growing community of inventors

Cologne, Germany

Wolf Kloeckner