University of Texas System

Max-delbrueck-centrum Fuer Molekulare Medizin

Max-delbruck-centrum Fur Molekulare Medizin

Omeicos Therapeutics Gmbh

Max-delbrueck-centrum Fuer Molekulare Medizin (mdc)

Max-delbruck-centrum Fur Molekulare Medizin in Der Helmholtz-gemeinschaft

Wolf-Hagen Schunck

Robert Fischer

John Russell Falck

Gerd Wallukat

Dominik N Mueller

Narender Puli

Cosima Arnold

Anne Konkel

Tim Wesser

Janine Lossie

Dominik Müller

Dominik Muller

Nareuder Puli

Cosima Schmidt

Dominik N MÜLLER

The present invention relates to compounds according to general formula (I) which are metabolically robust analogues of bioactive lipid mediators derived from omega-3 polyunsaturated fatty acids (n-3 PUFAs) for use in treating or reducing the risk of developing or preventing: (i) neovascularization and/or (ii) inflammatory disorder, in particular, ophthalmic disorders associated with neovascularization and/or inflammation.

Analogs of CYP-eicosanoids for use in treating or preventing a disorder associated with neovascularization and/or inflammation

The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

Eicosanoid derivatives

The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.

CYP-eicosanoid derivatives

The present invention provides compounds (n-3 PUFA derivatives) of formula (I) that modulate conditions associated with cardiac damage, especially cardiac arrhythmias. 

Growing community of inventors

Berlin, Germany

Wolf-Hagen Schunck