Madaus Ag

Madaus Gmbh & Co.

Laboratoire Medidom Sa

Wolf Grimminger

Klaus Witthohn

Helga Zaeske

Alfons Carcasona

Pentti Hietala

Karl P Odenthal

Pierre Potier

Klaus Gorler

Klaus Goler

Pentti Heitala

Pentti H&ecirc;itala

The present invention provides a process for obtaining diacetylrhein, wherein diacetylrhein containing aloe-emodin components is subjected to a liquid&mdash;liquid partitioning between a polar organic solvent which is only partly miscible with water and an aqueous phase of pH 6.5 to 7.5 and the diacetylrhein is recovered and optionally recrystallized. The present invention is also concerned with diacetylrhein obtainable by this process and with pharmaceutical compositions containing it.

Process for production of diacetylrhein

The present invention provides a process for treating arthritis utilizing substantially pure diacetylrhein having an aloe-emodin content of less than 20 ppm.

Method of preparing diacetyl rhein

Sennosides A, B and Al of the formula: ##STR1## which are substantially free from sennosides C, D and Dl, and from aloe-emodin derivatives, are prepared by a process wherein a) a sennoside mixture is reduced to rhein-9-anthrone-8-glucoside and aloe-emodin-9-anthrone-8-glucoside, b) a liquid-liquid partitioning of the compounds obtained is carried out between a polar organic solvent which is only partly miscible with water and an aqueous phase and c) the rhein-9-anthrone-8-glycosides contained after the partitioning in the aqueous phase is again oxidized to the corresponding sennosides and these are recovered.

Method of extracting sennosides A, B and A1

Diacetylrhein which is substantially free of aloe-emodin components, is prepared by a process wherein

The present invention provides a process for obtaining diacetylrhein, wherein diacetylrhein containing aloe-emodin components is subjected to a liquid-liquid partitioning between a polar organic solvent which is only partly miscible with water and an aqueous phase of pH 6.5. to 7.5 and the diacetylrhein is recovered and optionally recrystallised. The present invention is also concerned with diacetylrhein obtainable by this process and with pharmaceutical compositions containing it.

Compounds of the formula ##STR1## wherein R.sub.1 to R.sub.8, which may be identical to or different from each other, have diverse meanings, and the dotted line between the carbon atoms in the 4- and 4a- position or the 4a- and 5-position or the 42- and 12a position may be a single or double bond, or pharmaceutically acceptable salts thereof, as well as a process for the preparation of these compounds, and pharmaceutical compositions containing these compounds. The compounds and their salts are useful for the treatment of heart-circulation disorders.

Indole compounds, a process for their preparation, and pharmaceutical

A method for preparing azoniaspironotropanol esters, esters thus produced, and methods of use for these is disclosed. The esters are effective as broncholytics and as agents in therapy of asthmatic conditions.

Process for the preparation of azoniaspironortropanol esters

The present invention is concerned with the use of azoniaspironortropanol esters of the general formula: ##STR1## wherein R signifies one of the following radicals: (a) an alkylene radical of the general formula: ##STR2## in which R.sub.3 is a hydrogen atom or an alkyl, benzyl, aryl or alkoxy radical and n is a whole number of from 1 to 4,

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Bergisch Gladbach, Germany

Wolf Grimminger