Bayer Aktiengesellschaft

Wayne State University

Wolf-Dieter Busse

Mithat Mardin

Friedel Seuter

Friedrich Hoffmeister

Elisabeth Perzborn

Klaus Schlossmann

Edmund Krauthausen

Dieter Mayer

Volker Fiedler

Horst Meyer

Harald Horstmann

Siegfried Raddatz

Eike Moller

Rudolf Sundermann

Rudi Grutzmann

Kenneth V Honn

Ekkehard Niemers

A therapeutic method for reducing metastasis is disclosed. The method involves administering a therapeutically effective amount of 3-methyl-1-[2-(2-naphthyloxy)-ethyl]-2-pyrazolin-5-one or a pharmaceutically acceptable salt.

Method for treating human tumor cell metastasis

A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.

Nafazatrom as a lipoxygenase inhibitor

The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.

Anti-thrombotic pharmaceutical compositions comprising

The invention relates to pyrazolooxazines, pyrazolothiazines and pyrazoloquinolines defined herein by Formula I. The invention also includes compositions containing said Formula I compounds and methods for the use of said compounds and compositions for their lipoxygenase-inhibiting properties. Also included in the invention are methods for the manufacture of said compounds of Formula I.

Pyrazolooxazines, pyrazolothiazines, and pryazoloquinolines and their

The invention relates to cyclic sulphenamides of Formula I and methods for their manufacture. Also included in the invention are compositions containing said cyclic sulphenamides and methods for the use of said compounds and compositions as lipoxygenase inhibitors.

Cyclic sulphenamide compounds, their production and their medicinal use

The invention relates to sulphenamide compounds of Formula (I) as defined herein and to methods for their preparation. Also included in the invention are compositions containing said sulphenamide compounds; and the use of said compounds and compositions as lipoxygenase inhibiting agent.

Sulphenamides-containing lipoxygenase inhibiting agents and their use in

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Wuppertal, Germany

Wolf-Dieter Busse