Instytut Chemii Bioorganicznej Pan

Wojciech T Markiewicz

Marcin Krzysztof Chmielewski

Jan Barciszewski

Eliza Wyszko

Ewelina Adamska

Maria Markiewicz

Katarzyna Rolle

Beata Plitta

Malgorzata Giel-Pietraszuk

Agnieszka Fedoruk-Wyszomirska

Tadeusz Kulinski

Monika Nowak

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula  where Ris H, R, R, 2'-deoxyribosyl, Ris alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then Ris no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then Rand Rare independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation

The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti-aging composition. As 4-furfurylcytosine and/or its derivatives possesses a series of biological properties it might be use as a composition having excellent anti-aging effect to prevent the sagging of skin and loss of luster and to improve sufficiently its aesthetic appearance without significantly change the growth rate and the total growth ability of the skin. Optimal methods of manufacturing this compound, while at the same time obtaining the highest possible process efficiency, with particular emphasis on its utility in the pharmaceutical and cosmetic industries are presented.

Method of obtaining of 4-N-furfurylcytosine and/or its derivatives, an anti-aging composition and use of 4-N-furfurylcytosine and/or its derivatives in the manufacture of anti-aging composition

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Poznan, Poland

Wojciech T Markiewicz