Arqule, Inc.

Woj Wrona

Mark Anthony Ashwell

Yanbin Liu

Syed M Ali

Jason J Hill

Manish Tandon

Peter Lohse

Belew Mekonnen

Jifeng Liu

Robert Selliah

Valery Antonenko

Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof 

1,4-disubstituted naphthalenes as inhibitors of p38 map kinase

In general, the present invention relates to compounds capable of inhibiting p38, methods for inhibiting p38 in vivo or in vitro, and methods for treating conditions associated with p38 activity or cytokine activity.

Inhibitors of P38 and methods of using the same

1,4 disubstituted napthylenes, of formula (I), are disclosed. These compounds may be useful in treating cell-proliferative diseases. 

1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase

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Waltham, MA, United States of America

Woj Wrona