Dcb-USA LLC

Academia Sinica

Development Center for Biotechnology

Woan-Eng Chan

Jiann-Shiun Lai

Yuan-Tsong Chen

Chao-Yang Huang

Chih-Yung Hu

Ying-Yung Lok

Hung-Ling Wang

An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO:195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.

Anti-granulysin antibodies and methods of use thereof

The invention provides antibodies and polypeptides that specifically bind to the glycoprotein D of herpes simplex virus (HSV) and use of the antibodies and polypeptides for treating or diagnosing HSV infections.

Anti-herpes simplex virus antibodies and methods of use thereof

Growing community of inventors

Xizhi, Taiwan

Woan-Eng Chan