Pharmaseq, Inc.

Other

P-chip IP Holdings Inc.

Antyra Inc.

Dgi Biotechnologies, Inc.

Pharma Seg, Inc.

Wlodek Mandecki

Ioannis Kymissis

Young-June Yu

Robert Patti

William E Eibon

Von Ertwine

Joseph Wagner

Conrad Styczen

Efrain Rodriguez

Ziye Jay Qian

Richard D Morris

Maryann Gruda

Arthur J Blume

Renee Brissette

Juan Carcamo

Ziye “Jay” Qian

Pauline M Tang

Zhuying Wang

James Reginald Croft

Efrain “Frank” Rodriguez

Edith Margaret Cawsey

Jeffrey Michael Webb

Ji Li

Wesley Kopacka

Hanan Davidowitz

Edward Kuspiel

Joseph Nolfo

Ziye (Jay) Qian

Gary H Reitnauer

Garry Thomas Jolley-Rogers

David Keith Yeates

Philip John Suter

An apparatus and system having an optical integrated circuit (referred to herein as an OMTP) configured for power on during discovery and optically communicating with the OMTP reader for the purpose of extracting data.

All optical identification and sensor system with power on discovery

A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Light-triggered transponder

Provided among other things is a method of affixing a small, single chip to a plastic item, the chip having a top surface having length and width dimensions, and having a height, the method comprising: (1) vacuum adhering a top-oriented surface of the chip to a probe of outer dimensions comparable to or smaller than those of the length and width; (2) conveying heat to the chip via the probe such that a bottom-oriented surface of the chip is sufficiently hot to melt the plastic; (3) applying via the probe the chip to the plastic such that the chip embeds in the plastic; and (4) releasing the chip from the probe, wherein the largest of the length and width is about 500 microns or less, and height is no more than about the smallest of length and width.

Microchip affixing probe and method of use

Provided among other things is a method of applying force to a macromolecule such as dsDNA to make an end more accessible, such as more accessible to ligation.

Devices and methods for assembling extremely long DNA molecules

Provided is a method of synthesis comprising: (I) providing separate reaction sequences to TABs; (II) utilizing reaction vessels configured to react a separate combinatorial building block with a moiety on a surface of a TAB; and (III) operating one or more TAB sorters comprising a TAB reader, a sorting tree comprising valves or switches and sorting nodes, and a monitor configured to detect TAB location, wherein the operating comprises serially conducting: (a) reacting distinct combinatorial building blocks in the reaction chambers with surfaces of TABs distributed in the reaction chambers; (b) operating a controller to operate the TAB sorters to segregate the TABs to allocations appropriate for the next assigned reaction, the operating including recycling TABs with ambiguous identity back through the sorter; and (c) repeating steps (a) and (b) as needed to complete 30% or more of the assigned sequences.

Genomic-scaled nucleic acid synthesis, and other combinatorial syntheses

Provided among other things is an analyzer for use with tabs placed in a vessel including: a stochastic sampling device adapted to receive the vessel; a light beam source adapted to enter the moving vessel and selectively illuminate tabs; an analytical signal receiver adapted to receive a signal indicative of an analytical process occurring on the surface of the tab as the tab is selectively illuminated; a tab ID receiver adapted to collect ID data from the tabs in coordination with their selective illumination; and a controller for associating identified tabs with analytical signals.

Compact analyzer for acquiring characteristics of small tabs placed in a vessel

Provided herein, among other things, is an assembly consisting of a tissue cassette or slide and an affixed transponder.

Tagging of tissue carriers with light-activated microtransponders

Provided herein, among other things, is an assembly comprising a pin or a piece of jewelry and a transponder affixed thereto. The transponder can be a very small, light-triggered transponder ('MTP').

Tagging of metal pins for mounted objects with light-activated microtransponders

Provided, among other things, is a multiplex assay comprising: conducting a fluorescence-developing assay on microtabs having at least one surface that shows plasmonic enhancement, wherein a plurality of the microtabs have unique probes affixed to their plasmonically enhanced surfaces; and measuring the fluorescence associated with the substrates and identifying the correlated probe by for the microtab. The microtabs can be, for example, MTPs that send a unique identifier, and the correlated probe can be identified by querying the MTPs for their identifier.

Metal nanoparticle structures for enhancing fluorescence-based assays

Provided are methods and apparatus including an injector system adapted for injecting a microchip comprising: an inserter comprising a rod or tube having a proximal and distal end and having a point at the distal end that defines a skin-piercing side of the inserter; a means for engaging the microchip near the distal end of the inserter, but removed in the proximal direction from the distal tip of the inserter, which means prevents rotation of an engaged microchip in two or three axes of rotation; and means for releasing the microchip from the inserter once the inserter has been inserted into a perforatable substrate.

Apparatus and method to deliver a microchip

Growing community of inventors

Princeton Junction, NJ, United States of America

Wlodek Mandecki