Oncothyreon Inc.

Wladyslaw A Budzynski

R Rao Koganty

B Michael Longenecker

Damayanthi Yalamati

Mark J Krantz

Zi-hua Jiang

Zi-Hua Jiang

Sham Gandhi

Michael B Longenecker

Rao Koganty

The present invention provides liposomal vaccines containing immunogenic lipopeptides that are capable of modulating the humoral and cellular immune responses in vivo.

Vaccine for modulating between T1 and T2 immune responses

The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.

Lipid A and other carbohydrate ligand analogs

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Edmonton, Canada

Wladyslaw A Budzynski