Ge Healthcare Bio-sciences Ab

Ge Healthcare Bio-sciences Corp.

Witold Bula

Pavel Alexeyevich Fomitchov

Yang Zhang

Carlos Zarate

Erwen Mei

Steve Goodson

Pavel A Fomitchov

A line confocal microscope system, comprising a scanning unit in the form of a mechanically driven scanning unit with a controllable a scanning trajectory and a two dimensional sensor unit operated in a rolling line shutter mode in synchronization with the scanning unit, wherein the scanning trajectory is set to have an acceleration part outside the field of view of the sensor unit.

System for synchronization in a line scanning imaging microscope

The present invention relates to a system and method for reducing image artifacts for a CMOS camera used as an optical detector for a line confocal fluorescent imager. The method for reducing image artifacts in a monochromatic image comprises subtracting RGB channel offset mismatch; and correcting random row offset for each row. Preferably, the method also comprises correcting random column offset and gain. Optionally, the method also comprises clipping of defective pixels, and/or subtracting dark current. When the monochromatic image is a fluorescence image, the method also comprises a step of compressing CMOS camera noise. Also provided are a system for reducing image artifacts in a monochromatic image from a CMOS camera, as well as an image artifact reduction system for a CMOS camera-based line confocal fluorescent microscope.

Method for reducing image artifacts produced by a CMOS camera

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St. Catharines, Canada

Witold Bula