The Salk Institute for Biological Studies

Witek Kwiatkowski

Ronald Mark Evans

Michael Downes

Annette R Atkins

Jae Myoung Suh

Senyon Choe

The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 2 and the C-terminus comprises a portion of an FGF1 protein, wherein the chimeric protein comprises at least 95% sequence identity to SEQ ID NO: 9, 10, 11, 12 or 13. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed molecules to reduce blood glucose levels are also provided.

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San Diego, CA, United States of America

Witek Kwiatkowski