Mcneil Ab

Mcneil Laboratories, Incorporated

Winston Ho

Richard J Mohrbacher

Gene F Tutwiler

Kerry G Stanley

Compounds useful as antihypertensive agents which are 3-aminoalkyl-1H-indole-5-urea or amide derivatives having the following formula: ##STR1## or a pharmaceutically acceptable acid addition salts thereof, wherein: R is C.sub.1-4 loweralkyl, C.sub.1-4 loweralkoxy, phenyl, ##STR2## pyrrolyl, pyridyl or is a substituted nitrogen represented by: ##STR3## wherein R.sub.1 is H or a C.sub.1-4 loweralkyl or phenyl or cycloalkyl; R.sub.2 is H or a C.sub.1-4 loweralkyl; Y is H or halo; R.sub.3 is H or a C.sub.1-4 loweralkyl; R.sub.4 is H or a C.sub.1-4 loweralkyl; R.sub.5 is H or a C.sub.1-4 loweralkyl or carboxymethyl or carboxytrifluoromethyl; R.sub.6 is H or a C.sub.1-4 loweralkyl, and R.sub.5 and R.sub.6 may also be taken together as an N-loweralkyl-pyrrolidinylidene group.

3-aminoalkyl-1H-indole-5-urea and amide derivatives

Hydroxythioether fatty acid derivatives of formula (I) ##STR1## wherein n is 2-5, m is 8-12, R.sup.1 is OH, O-loweralkyl, NH.sub.2, NH-loweralkyl or NH-carboxyalkyl; R.sup.2 is OH or O-loweralkyl; X is H or NH.sub.2 or ##STR2## and salts thereof are useful in preventing or alleviating asthma or other allergic diseases.

Saturated leukotriene derivatives as antiallergens

Hydroxythioether fatty acid derivatives of formula (I) ##STR1## wherein n is 2-5, m is 8-12, R.sup.1 is OH, O-loweralkyl, NH.sub.2, NH-loweralkyl or NH-carboxyalkyl, R.sup.2 is OH or O-lower-alkyl, X is H or NH.sub.2 or ##STR2## and salts thereof are useful in preventing or alleviating asthma or other allergic diseases.

Hydroxythioether fatty acid derivatives

Hypertension is controlled by administration of glycidic or thioglycidic acid derivatives substituted in the .alpha.-position with a long chain alkyl or alkenyl or dibromoalkyl radical.

Method for controlling hypertension

Glycidates and thioglycidates substituted in the .alpha.-position with a long chain alkyl of from 11 to 16 carbons having hypoglycemic activity.

.alpha.-Alkyl-substituted glycidates and thioglycidates

Glycidic acid derivatives substituted in the 2-position with a long chain alkenyl of from 11 to 16 carbons having hypoglycemic activity.

Alkenylglycidic acid derivatives

Glycidic acid derivatives substituted in the 2-position with a long chain dibromoalkyl of from 11 to 16 carbons having hypoglycemic activity.

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Hatfield, PA, United States of America

Winston Ho