Gilead Sciences, Inc.

K.u. Leuven Research & Development

Gilead Pharmasset LLC

Other

Gerhard Puerstinger

Puerstinger, Gerhard

Winston C Tse

John O Link

Scott D Schroeder

Jennifer R Zhang

Qi Liu

Randall Halcomb

Michael Graupe

Eda Y Canales

Steven S Bondy

James G Taylor

Jeromy J Cottell

Scott E Lazerwith

Darryl Kato

Gediminas J Brizgys

Randall W Vivian

Elizabeth M Bacon

Richard L Mackman

William John Watkins

Choung U Kim

Manoj C Desai

Aesop Cho

Michael L Mitchell

Lianhong Xu

Thorsten A Kirschberg

Jay P Parrish

Hongtao Liu

Hongyan Guo

Carina E Cannizzaro

Jianyu Sun

Hyung-Jung Pyun

Chienhung Chou

David A Oare

Dimitrios Stefanidis

Jiayao Li

Qiaoyin Wu

Zheng-Yu Yang

Bing Shi

Reza Oliyai

Vahid Zia

Kevin S Currie

Chandrasekar Venkataramani

Barton W Phillips

Sheila M Zipfel

Michael O'Neil Hanrahan Clarke

Xianghong Wang

Elbert Chin

Nathan E Wright

Haolun Jin

Samuel E Metobo

Michael R Mish

Ryan McFadden

Roland D Saito

Yunfeng Eric Hu

James D Trenkle

Joseph H Saugier

Evan S Krygowski

Chien-Hung Chou

Chien-hung Chou

Scott Alan Wolckenhauer

Terrence C Dahl

Charles William Rowe

Anna Chiu

Anna Michelle Wagner

Vinh Xuan Ngo

Trevor James Rainey

John R Somoza

Amanda Lynn Vandehey

Brian Michael O'Keefe

Dana J Levine

Stephen R Yant

Nathan D Shapiro

Evangelos Aktoudianakis

Willard Lew

Tomas Cihlar

Lars V Heumann

Terry Kellar

Eric Gorman

Yafan Lu

Benjamin James Roberts

Kyla Bjornson

Zilin Huang

Steven J Henry

Dietrich P Steinhuebel

Shahrokh Kazerani

Randall L Halcomb

Elena Bekerman

Sachin Dhar

Ruchika Mishra

You-chul Choi

Qui Liu

Hyung-Jun Pyun

Wade S Blair

Jim X Zheng

Laura Elizabeth Bauer

Andrew Stephen Mulato

Martin Sunkwang Rhee

Scott P Sellers

Chloe Y Wong

The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

Capsid inhibitors for the treatment of HIV

The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

Therapeutic compounds

The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

The present disclosure provides methods of preventing HIV in a subject, comprising administering to the subject a therapeutically effective amount of a compounds of Formula (Ia) or (Ib): or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. Methods of reducing the risk of acquiring HIV (e.g., HIV-1 and/or HIV-2) are also provided.

Capsid inhibitors for the prevention of HIV

The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Methods and intermediates for preparing therapeutic compounds

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus. 

Compounds for the treatment of HIV

The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

Compounds for the treatment of hepatitis B virus infection

Pyrrolo[1,2-b]pyridazine derivatives

Growing community of inventors

Redwood City, CA, United States of America

Winston C Tse