E. R. Squibb Sons, Inc.

Other

Wing-Sun Chow

Richard W Walton

Peter Timmins

Donald C Monkhouse

Shirley C Chen

Donna A D'Stefan

An anti-fungal complex formed of a polyene anti-fungal agent, such as amphotericin B, and cyclodextrin, preferably .gamma.-cyclodextrin, is provided. The complex which includes amphoterin B has improved water solutility and stability over prior art amphotericin B anti-fungal agents. A method for forming the complex is also provided wherein anti-fungal agent, such as amphoterin B, is dissolved in an aqueous solution of cyclodextrin of pH ranging from about 9 to about 12 and the resulting solution is maintained at a pH ranging from about 6 to about 8 to form the subject complex. The solution can be lyophilized as desired to achieve higher solubility.

Complex of anti-fungal agent and cyclodextrin and method

A controller for a two-directional air pump, of the type used in performing medical experiments is described. The controller includes a level sensing apparatus which is used to initiate an electric signal which controls a pneumatic solenoid which toggles the two-directional pump. Using the apparatus, the Doluisio technique may be performed automatically.

Automated control for a two-directional pump

A steroid formulation is provided which is preferably in the form of a lotion or cream and contains a steroid, such as halcinonide, a polyol vehicle therefor, such as polyethylene glycol, and dipotassium ethylenediaminetetraacetic acid which is soluble in the polyol vehicle and inhibits metal catalyzed degradation of the steroid.

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Upper Montclair, NJ, United States of America

Wing-Sun Chow