St. Jude Children's Research Hospital

Miltenyi Biotec B.v. Co., Kg

Wing Leung

Stefan Miltenyi

Rafijul Bari

Markus Granzin

Andrzej Dzionek

Volker Huppert

Martin Meyer

Nina Moker

Wai-Hang Leung

Julia Dzionek

Nina MÖKER

The present invention discloses an in-vitro method for transferring biological material into activated NK cells with a pseudotyped retroviral vector particle or a virus-like particle thereof, comprising the steps a) activation of NK cells, and b) addition of said pseudotyped retroviral vector particle or virus-like particle thereof to said activated NK cells, wherein said pseudotyped retroviral vector particle or virus-like particle thereof comprises a modified baboon endogenous retrovirus (BaEV) envelope glycoprotein that is able of binding to and fusing with a hematopoietic cell membrane, thereby transferring biological material into said activated NK cells. Preferentially, the activating of NK cells is performed by the addition of a IL-1 family cytokine to the NK cells.

Method for NK cell transduction

The present invention discloses a chimeric antigen receptor (CAR) comprising an antigen binding domain specific for BDCA2, a population of engineered cells expressing said CAR and a pharmaceutical composition thereof. Said engineered cells are for treatment of cancer in a subject, wherein the cancerous cells of said cancer express BDCA2 such as Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN).

Chimeric antigen receptor specific for BDCA2 antigen

A nucleic acid construct and mammalian cell harboring nucleic acids encoding an anti-CD7 chimeric antigen receptor are provided. Methods for treating cancer, in particular a hematologic cancer, using the nucleic acid construct or mammalian cell are also described.

Anti-CD7 chimeric antigen receptor and method of use thereof

The invention is directed to the use of Retinoid X Receptor-gamma (RXR-gamma) agonists and Retinoid X Receptor-alpha (RXR-alpha) antagonists in treatment of cancer.

Retinoid X receptor-gamma agonists and retinoid X receptor-alpha antagonists for treatment of cancer

Growing community of inventors

Memphis, TN, United States of America

Wing Leung