City University of Hong Kong

The University of Hong Kong

Wing Fu Lai

Ho Cheung Shum

Andrei Rogatch

The invention relates to a drug delivery device adapted for carrying and delivering both hydrophilic and lipophilic drug molecules. The drug delivery device includes a porous body for adsorption of drug molecules, the body including a plurality of microspheres, and a hydrogel forming cross-links connecting the plurality of microspheres.

Drug delivery device and its method of manufacture

Described herein is a drug delivery system, which is based on a novel polymer namely hypromellose-graft-chitosan (HC), useful to deliver a drug to a patient in sustained and controlled release fashion. HC is highly water soluble across the pH range from 1.2 to 10, and has a high pH buffering capacity to provide a pH-stable environment for drug delivery. In addition, the drug delivery system provided herein exhibited a drug loading efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by conventional chitosan, and achieved a 2-3 fold longer duration of sustained drug release.

Growing community of inventors

Hong Kong, China

Wing Fu Lai