Boehringer Mannheim Gmbh

Winfriede Sauer

Herbert Berger

Wolfgang Vomel

Alfred Rhomberg

Kurt Stach

Kurt Stach, Deceased

Rudi Gall

Max Thiel

Hartmut Merdes

By Werner Plattner, Administrator

By Werner Plattner, Executor

Werner Plattner, Administrator

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Compositions using cycloalkano-quinolone derivatives and their method of

New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,

Cyclopenteno[1,2-h]quinol-4-one derivatives

Nitrogen containing derivatives of cyclopenteno-quinolone compounds and

New cyclopenteno-quinolone derivatives of the formula ##SPC1## Wherein

Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic

Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1## Wherein

Cyclopentenoquinolone compounds for treating bacterial infections

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1## Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

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Mannheim-Wallstadt, Germany

Winfriede Sauer