Biocer Entwicklungs Gmbh

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Winfried Vonau

Helmar B Mayr

Jacques Rohayem

Sigrun Herrmann

Daniel Seitz

Guenter Ziegler

Frank Gerlach

Jörg Opitz

Jürgen Schreiber

Michael Mertig

Elke Boschke

Philipp Quenzel

Thomas Bley

Viktoria Alexejewna Lapina

Ada Lange

Sandra Päßler

Andrea Pohl

The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area. The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.

Arrangement for on-line measurements on cells

Growing community of inventors

Geringswalde, Germany

Winfried Vonau