Euroimmun Medizinische Labordiagnostika Ag

Winfried Stöcker

Christian Probst

Lars Komorowski

Martin Rateike

Anthonina Janssen

Yvonne Denno

Ramona Miske

Stefan Gerlach

Madeleine Scharf

Christian Marzahl

Alf Weimann

Wolfgang Schlumberger

Cornelia Dähnrich

Waltraud Suer

Inga-Madeleine Dettmann

Christian Kaffka

Jörn Voigt

Christian Feirer

Henning Seismann

Thomas Scheper

Wolfgang Meyer

Ulf Steller

Bianca Teegen

Sven Meuth

Rasmus Behring

Thomas Mothes

Erik Bernitt-Ringering

Simon Schwab

Vanessa Viertel

Antje Euken

Victor Herbst

Annika Jahnke

Katja Morgenroth

Nico Melzer

Heinz Wiendl

Bianca Maltzahn

Birgit Wichner

An apparatus is proposed for identifying respective cover slip regions of respective cover slips having respective tissue sections on a specimen slide, which has multiple optical identifiers. The apparatus includes a planar light source, an image acquisition unit, a holding unit for positioning the specimen slide between the planar light source and the image acquisition unit, a slit diaphragm, which has multiple opening slits, reversibly positionable between the planar light source and the specimen slide, and an illumination unit, which is designed to illuminate that surface of the specimen slide which faces toward the image acquisition unit. Furthermore, the apparatus includes a monitoring unit which is designed, on the basis of a completely illuminated transmitted light image, an incident light image, and a partially darkened transmitted light image, to assign respective tissue sections to respective optical identifiers.

Apparatus and method for detecting coverslip regions of a specimen slide

An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.

Incubation device and system comprising incubation device and rocking platform

A method is useful for automated detection of antibodies in a liquid biological sample with an antigen chip having antigen spots which are applied thereon and which have an identical, common dye. The antigen spots form respective antigen spot sets which form corresponding respective, regular antigen spot patterns. Furthermore, reference spots comprising the identical dye are applied, and form a reference spot set which forms a regular reference pattern. The reference pattern differs with respect to its regularity from the antigen spot patterns. Through a first image information item which represents a color of the reference spots and of the antigen spots due to the identical, first dye and through a second image information item which represents a potential color of the antigen spots due to a second dye after an incubation, binding of antibodies of the biological sample to respective antigen types is then determined by image processing.

Method for automated detection of antibodies in a liquid biological sample using an antigen chip, and antigen chip therefor

A device for incubating an immunoblot strip () includes at least one incubation channel () into which an elongate immunoblot strip () having at least one biological material on its front is inserted with its back facing a channel base (). An agitating means (), with which the immunoblot strip () is agitatable around a transverse axis () of the strip () at least at times during incubation via an agitating device (). For handling and/or grouping incubation channels () with immunoblot strips () inserted, a rack () for taking up at least two incubation channels () is provided. The rack () is in operative connection with said agitating means () via load transmission points.

Testkit for laboratory diagnostics

Polypeptides including Neurochondrin and autoantibodies binding to polypeptides including Neurochondrin are provided. Methods for diagnosing or treating diseases associated with neurological symptoms or cancers are also provided. The methods of diagnosis may include detecting an autoantibody binding to Neurochondrin in a sample from a patient. The methods of treatment may include administering a polypeptide comprising Neurochondrin to a patient.

Detection of anti-neurochondrin autoantibody in patients with cerebellar ataxia or cerebellitis

The invention relates to a device for performing immunological, histochemical and cytochemical, molecular biological, enzymological, clinical-chemical and other analyzes, wherein the device comprises an object holder having one or more elongate adhesive surfaces and a reagent holder having one or several channels. The object holder is detachably connectable to the reagent holder in such a manner that the elongate adhesive surfaces each face one of the channels and, when reaction partners bound to a solid phase are disposed on the elongate adhesive surfaces and reactants dissolved in liquid are present in the channels, the reaction partners and the reactants are in contact. Means are provided for preventing the liquid from passing from one channel into an adjacent channel. A method for performing a corresponding analysis can be performed with this device, by connecting the object holder to the reagent holder in such a manner that the elongate adhesive surfaces each face a channel, liquid having reactants dissolved therein is introduced into the channels such that the solid phase substrates having reaction partners bound thereto and being disposed on the adhesive surfaces come into contact with the liquid, and the object holder and the reagent holder are moved together in such a manner that the liquid alternately moves into the two longitudinal directions of the channels.

Analyzing methods and devices for biological reactions between a liquid phase and a solid phase

The present disclosure relates to proteins derived from OspC from bacteria of the genus, in particular a protein which comprises a first OspC polypeptide, wherein the first OspC polypeptide is linked to a second OspC polypeptide via a disulphide bridge. The disclosure also relates to a method for the detection of antibodies against OspC and a method for the detection of ainfection, wherein a protein according to the disclosure is employed, and also to a diagnostic kit and a vaccine against

Polypeptides and methods for the specific detection of antibodies in patients with a borrelia infection

[object Object]

The present invention relates to fusion peptides that are derived from components of gliadin, to a method and reagents for the serological diagnosis of celiac disease or dermatitis herpetiformis by way of assaying antibodies that are directed against modified gliadin. The invention also relates to methods and pharmaceutical compositions for treating said diseases by specific immunoabsorption of these antibodies.

Method and immunoabsorbents for specific detection and absorption of antibodies associated with celiac disease and dermatitis herpetiformis

Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or delaying the onset of a rise in blood glucose levels in an animal, comprising administering to the animal an antisense inhibitor of PTP1B expression in combination with at least one glucose-lowering drug. The present invention is also directed to compositions and methods for improving insulin sensitivity in an animal or for preventing or delaying the onset of insulin resistance in an animal. Also provided are compositions and methods for treating or preventing a metabolic condition in an animal. The metabolic condition may be, e.g., diabetes or obesity.

Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (DLE)

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Gross Groenau, Germany

Winfried Stöcker