Euroimmun Medizinische Labordiagnostika Ag

Winfried Stoecker

Christian Probst

Lars Komorowski

Yvonne Denno

Ramona Miske

Madeleine Scharf

Lars Koschinat

Bianca Huth

Alexander Kowtun

Stephanie Kade

Frank Mollenhauer

Iswariya Venkataraman

Lars Richter

Christiane Radzimski

Wolfgang Schlumberger

Inga-Madeleine Dettmann

Alf Weimann

Stefanie Hahn

Henning Seismann

Bianca Teegen

Patrick Auer

Anthonina Janssen

Detlef Zillikens

Marian Fuchs

Thorsten Hanhoff

Norbert Koop

Norbert Rottmann

George Trendelenburg

Christoph Hammers

Annika Jahnke

Enno Schmidt

Stephanie Goletz

A pressure-tight storage vessel contains a liquid, has an elongated main body rotationally symmetrical with respect to an axis of symmetry, and forms, at least partially, a rotationally symmetrical hollow space in which the liquid is substantially received, wherein the main body is terminated at its bottom side by a base. Furthermore, at its top side, the storage vessel has an opening which is closed off in a pressure-tight manner by a closure, has a plurality of reinforcement elements, which bears against the main body at the outside, which extends parallel to the axis of symmetry of the main body, and arranged rotationally symmetrically about the axis of symmetry of the main body. In each case between adjacent reinforcement elements, respective externally exposed wall sections of the main body are formed, and the composition of the exposed wall sections permits a pressure-tight insertion by at least two hollow needles.

Pressure-tight storage vessel containing a liquid

The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a polypeptide comprising a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, or a variant thereof, a use of said polypeptide for the diagnosis of a disease, an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a use of the autoantibody for the diagnosis of a disease, a method for isolating an autoantibody binding to a polypeptide selected from the group comprising NSF, STX1B, DNM1 and VAMP2, a pharmaceutical composition or medical device comprising said polypeptide according to the present invention, a kit for the diagnosis of a disease comprising said polypeptide or said medical device and a use of said polypeptide or autoantibody for the manufacture of a kit or medical device.

Diagnosis of a neuroautoimmune disease

A polypeptide contains laminin beta-4 and a carrier contains the polypeptide. An antibody, preferably autoantibody, is against laminin beta-4. Furthermore, use of the polypeptide, carrier or autoantibody for the diagnosis of a disease, and a method with the step of detecting an autoantibody against laminin beta-4 in a sample are described.

Diagnosis of blistering autoimmune disease

Capillary vessel

The present invention relates to a method for diagnosing a disease comprising the step detecting in a sample comprising antibodies from a patient and also antibody binding to RGS8, a method for diagnosing a disease comprising the step detecting in a sample from a patient the level or activity of RGS8, a polypeptide comprising RGS8 or a variant thereof, a use of set polypeptide for the diagnosis of a disease, an antibody binding to RGS8, a use of the antibody for the diagnosis of the disease, a method for isolating an autoantibody binding to RGS8, a pharmaceutical composition or medical device comprising the polypeptide according to the present invention, a kit for the diagnosis of a disease comprising the polypeptide or the medical device according to the present invention and a use of the polypeptide, the antibody or the antibody for the manufacture of a kit or medical device.

The present invention relates to a method for the diagnosis of a disease comprising contacting a donor tissue section with a liquid capable of extracting an antibody from said donor tissue section and contacting said liquid with an acceptor material comprising an antigen, followed by detection of a complex comprising the antibody and the antigen, and a diagnostically useful carrier comprising a donor tissue section and an acceptor material comprising an antigen.

Diagnostic coincubation assay

The present invention relates to a pressure-tight storage vessel containing a liquid, wherein the storage vessel has an inner floor and an upper side and is closed in a pressure-sealing manner by a closure, and wherein the nature of the storage vessel allows pressure-sealing piercing with at least two hollow needles; and to a method for transferring a liquid from a storage vessel to a reaction vessel, the method comprising the following steps: supplying the storage vessel according to the invention, pressure-sealing piercing with a first hollow needle, which is connected to a rinsing-liquid tank, and pressure-sealing piercing with a second hollow needle, which is connected to the reaction vessel, introducing rinsing liquid from the rinsing-liquid tank, via the first hollow needle, into the storage vessel, the liquid being driven out of the storage vessel, via the second hollow needle, into the reaction vessel; and to an apparatus which is suitable for implementing the method according to the invention.

Method and device for transferring liquids

A method for diagnosing a disease by detecting an autoantibody that binds to flotillin1 and/or flotillin2 in a sample, a polypeptide comprising flotillin1 and/or flotillin2 or a variant thereof, which may be immobilized, a method of treating a disease by applying to a subject the polypeptide that binds to an autoantibody, an autoantibody binding to flotillin1 and/or flotillin2, a method for isolating the autoantibody, a pharmaceutical composition, a medical device and test kit comprising the polypeptide, are provided. A method for detecting the presence of an autoantibody is also provided.

Diagnosis of a neuroautoimmune disease comprising measuring autoantibodies to flotillin1 and/or flotillin2

The invention relates to a transparent object carrier, which has a marking impressed in the interior, to a diagnostic instrument, preferably a microscope, in combination with a transparent object carrier inserted for diagnostic analysis, and to a method, comprising the steps of providing a transparent object carrier, impressing a marking, which is located in the interior of the carrier, supplying the transparent object carrier with a biological or chemical sample, and, optionally, dividing the transparent object carrier and thereby producing a plurality of smaller transparent object carriers that enclose material from the biological or chemical sample.

Transparent microscope slide having a marking

The invention relates to a device for bringing an immobilized reactant into contact with at least one fluid, said device comprising: a basin having a bottom surface from which an upper side of at least one elevated portion projects into the interior of the basin, and said at least one elevated portion having a channel running, preferably perpendicular to the bottom surface of the basin, from the bottom surface of the basin to the upper side of the portion, and leading into at least one outlet opening on the upper side of the elevated portion, wherein the channel is fed from at least one fluid reservoir via a supply element by means of a pump device, said reservoir containing the at least one fluid; a holding device designed to detachably hold at least one object carrier, preferably a plurality of object carriers, having at least one surface of adhesion to the immobilized reactant, in such a way that the adhesion surface is facing the interior of the basin, and the upper side of the elevated portion and the adhesion surface are positioned relative to one another in such a way that fluid exiting the outlet opening comes into contact with the immobilized reactant; and optionally an object carrier introduced into the holding device. The invention also relates to a method for bringing an immobilized reactant into contact with at least one fluid, comprising the following steps: immobilizing the reactant on the adhesion surface of at least one object carrier suitable for introduction into the holding device of the device according to the invention; (provided that the preceding steps were carried out outside of the device according to the invention) introducing the object carrier into the holding device of the device according to the invention, preferably via a transport device in the device according to the invention; introducing the at least one fluid via the supply element in the direction of the outlet opening, until the at least one fluid comes into contact with the immobilized reactant.

Device and method for reactions between a solid and a liquid phase

Growing community of inventors

Gross Groenau, Germany

Winfried Stoecker