Bayer Aktiengesellschaft

Orpegen Medizinisch-molekularbiologische Forschungsgesellschaft M.b.h.

Orpegen Medizinische-molekular Biologische Forschungsgesellschaft Mbh

Winfried Kosch

Joachim Marz

Axel Kretschmer

Burkhard Mielke

Eckhard Schwenner

Udo Stropp

Horst Kunz

Walter Weichel

Christoph Schwemler

Klaus Luttermann

Edgar Diessel

Thorsten Potter

Hansjorg Durr

Horst Kung

The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled with a fluorescent dye are mixed with the molecule library which is in the form of a suspension. The mixture is plated out on a two-dimensional substrate ( ) after the excess, unbound ligands have been washed out. Then the local fluorescence intensities on the substrate are electro-optically identified in a fluorescence microscope ( ) and electronically discriminated in accordance with given selection criteria. The objects selected and localised in this way are then sequentially positioned exactly by a displacement, the coordinates of which are controlled by the image calculator, between the substrate ( ) and a separation actuator ( ) and are spatially separated from the substrate ( ) by the separation actuator ( ).

Process and device for the screening of molecules with regard to their individual binding behaviour towards at least one given ligand

The present invention relates to compounds of the general formula (I), ##STR1## in which the radicals have the meaning given in the description, to processes for their preparation and to their use as medicaments.

Nucleic acid-binding oligomers for therapy and diagnosis

The invention provides a method for the production of a solid phase system of the formula F--(--R.sup.3 --Y--CO--CR.sup.2 .dbd.CR.sup.1 --CH.sub.2 --X).sub.m using new allyl esters of the formula:

Process for preparation of a solid phase system

The present invention provides new allyl esters of the general formula:

Allyl esters and the use thereof for the build-up of solid phase systems

Growing community of inventors

Wiesbaden, Germany

Winfried Kosch