Smithkline Beckman Corporation

Winfred J Sanders

Govind K Menon

Thomas O Lindsey

Alfred W Chow

Selected 2-(.alpha.-pyridyl)-.DELTA..sup.2 -heterocyclic compounds are used as active ingredients in animal feed compositions and in methods for increasing the growth or feed efficiency of monogastric animals. An active ingredient for use in this invention is 3,4-dihydro-4-hydroxy-5-(3-hydroxy)-2-pyridinyl)-4-methyl-2H-pyrrole-5-car boxamide.

Feed compositions containing 2-(.alpha.-pyridyl)-.DELTA..sup.2

Selected pyridylalkylhydrazides are used as active ingredients in animal feed compositions and in methods for increasing the growth and feed efficiency of monogastric, meat-producing animals. A particularly useful active ingredient of this invention is 3-azabicyclo-[3.2.2]nonane-3-carbothioic acid 2-[1-(2-pyridyl)ethyl]-hydrazide.

Feed compositions containing pyridylalkylhydrazides

Selected (1-oxo-2-pyridyl) disulfides are used as active ingredients in animal feed compositions and in methods for increasing the growth and feed efficiency of monogastric animals. A useful new compound of this invention is 2-carboxyphenyl (1-oxo-2-pyridyl) disulfide.

Feed compositions containing a (1-oxo-2-pyridyl) disulfide

Dialkyl 1-(2-pyridinylthio)-1,2-hydrazinedicarboxylate, N-oxides are prepared by reacting a 2-mercaptopyridine-N-oxide and a dialkyl azodicarboxylate. The end products are useful as antimicrobial agents and, especially, growth promotants in monogastric meat producing animals. A species of the group is diethyl 1-(2-pyridinylthio)-1,2-hydrazinecarboxylate, N-oxide.

Dialkyl 1-(2-pyridinylthio)-1,2-hydrazinedicarboxylate, N-oxides and

Copper salts of 2-hydroxypyridine-N-oxides have been demonstrated to possess an ability to alter the metabolic pattern in the digestive tract of food producing animals to make energy producing metabolic units which are more available for absorption by the animals. The copper salts, such as cupric 2-hydroxypyridine-N-oxide, are active ingredients in feed compositions and methods for increasing growth and feed efficiency of these animals.

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Mt. Holly, NJ, United States of America

Winfred J Sanders