Alchemia Limited

Alchemia Pty Ltd

Vast Bioscience Pty Limited

Wim F Meutermans

Michael Leo West

Gerald B Tometzki

Karl Schafer

George Adamson

Johannes Zuegg

Giovanni Abbenante

Craig Muldoon

Giang Thanh Le

Bernd Becker

Fiona Foley

Natalie Bouloc

Matthias Grathwohl

Premraj Rajaratnam

Darren Schliebs

Tracie E Ramsdale

Nicholas B Drinnan

Ligong Liu

Peter Andrews

Glang Le Thanh

Judy Halliday

Declan McKeveney

Rajaratnam Premraj

Thanh Le Giang

Giang Le Thanh

Chris Clark

Giovani Abbenante

The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).

Method of drug design

A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.

Compounds that interact with kinases

New compounds and methods for the preparation of combinatorial libraries of potentially biologically active compounds are based on monosaccharides of formula I being a derivative of a furanose or pyranose form of a monosaccharide, .

Derivatives of monosaccharides for drug discovery

A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I.

Monosaccharide compounds and methods therefor

The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.

Classes of compounds that interact with GPCRs

The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein: 

Antibacterial agents

Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

Disaccharides for drug discovery

This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

Anomeric derivatives of monosaccharides

A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I, 

Carbohydrate based anti-bacterials

Combinatorial libraries of monosaccharides

Growing community of inventors

Toowong, Australia

Wim F Meutermans