Centre National De La Recherche Scientifique

Institut Pasteur

Institute Pasteur

Instituto Gulbekian De Cienca

Instituto Gulbenkian De Cienca

Instituto Gulbenkian De Ciencia

Instituto De Ciencias Abel Salazar

Wim Degrave

Paola Minoprio

Armand Berneman

Catherine Rougeot

Mario Arala-Chaves

Bernardo Reina San Martin

Antonio Coutinho

Alain Cosson

Nathalie Chamond

Paolo Minoprio

Pedro Alzari

Alejandro Buschiazzo

Sara Isabel Mansinho Fernandes De Almeida, Legal Representative

Christophe Grégoire

Eduarda Maria Santos Dores Arala Chaves, Legal Representative

Christophe Gregoire

Rui Mario Dores Arala Chaves, Legal Representative

Eduarda Maria Santos Dores Arala-Chaves

Christophe Inst Gulbenkian De Ciencia Gregoire

A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.

Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens

The present invention provides the crystal structure of thePRACA proline racemase. Methods of modelling drugs that treat or prevent infection byare also provided, as are the drugs that are identified.

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A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen, such as a eukaryotic amino acid racemase, in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.

Crystallographic structure of TcPRACA and uses therefor

This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs and more specifically SEQ ID NOS: 1-4. This invention also relates to antibodies specific for the peptides and to immune complexes of these antibodies with the peptides. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

Identification and characterization of racemases, definition of protein signatures, and a test for detecting D-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase

This invention provides identification and characterization of racemases and definition of protein signatures of these racemases. This invention also provides identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs. Antibodies specific for the peptides and to immune complexes of these antibodies with the peptides are also provided. Further, the invention relates to methods and kits for detecting racemases using the nucleic acid molecules of the invention, as well as the peptides consisting of the motifs and antibodies to these peptides.

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Rio de Janeiro, Brazil

Wim Degrave