Janssen Pharmaceutica Nv

Universiteit Gent

Biorem Engineering Sarl

Wim De Windt

Willy Verstraete

Nico Boon

Tom Van De Wiele

Tom Defoirdt

Mariane Van Wambeke

Tom Vercauteren

Frédéric Lakaye

Jonathan Ernotte

This invention relates to the use of hydroxybutyrate and poly hydroxybutyrate as components of animal feed or feed additives, as well as to compositions, feed additives and feed containing them. The inventors surprisingly found that hydroxybutyrate and poly-hydroxybutyrate, preferably 3-hydroxybutyrate and poly-3-hydroxybutyrate, have a great potential for use in animal feed for modulation of the gut flora. More precisely, it has been found that poly-3-hydroxybutyrate or a microbial strain capable for producing poly-3-hydroxybutyrate can be used as a potential growth promoter or gut flora modulator by releasing SCFA, preferably 3-hydroxy butyric acid, in the gut micro flora. Further, the inventors found that 3-hydroxybutyrate and poly-3-hydroxybutyrate have a great potential for suppressing or inhibiting pathogenic bacteria in the gastro intestinal tract, e.g. have a antimicrobial activity against strains ofand

Hydroxybutyrate and poly-hydroxybutyrate as components of animal feed or feed additives

This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising at least 4 mM of a silver or gold salt. A resulting nanosilver-containing composition is useful as a highly efficient antimicrobial agent, for instance when impregnated onto a carrier, or an algicide agent or a herbicide agent.

Method for producing metal nanoparticles

Silver nanoparticles associated with 20 to 80% by weight of a biocomponent of the genus, said silver nanoparticles having a ratio of the average particle size to the specific surface area (BET) of from 0.015 to 0.15 nm/m/g; a method for producing silver nanoparticles, comprising the step of incubating bacteria of the genuswith an aqueous solution comprising at least 4 mM of a silver salt in the presence of ammonia and an alkali metal hydroxide until a biomass of bacteria containing Agsilver nanoparticles is formed; and optionally a further step of extracting said Agsilver nanoparticles from said biomass by means of concentrated alkali metal hydroxide or concentrated inorganic acid or enzymes; an anti-microbial composition comprising an effective amount of said silver nanoparticles; use of said silver nanoparticles for the manufacturing of an article or a composition with anti-microbial activity; a method for manufacturing an article or a composition with anti-microbial activity, comprising dispersing or impregnating said silver nanoparticles into said article or composition; and an article with anti-microbial property having said silver nanoparticles dispersed therein.

Silver nanoparticles with specific surface area and a method for producing them

Growing community of inventors

Sint-Amandsberg, Belgium

Wim De Windt