Pharmafluidics Nv

Vrije Universiteit Brussel

Vrue Universiteit Brussel

Wim De Malsche

Paul Jacobs

Jeff Op De Beeck

Gert Desmet

Bo Claerebout

Tobias Vandermeersch

Ozlem Sardan Sukas

Manly Callewaert

Pierre Gelin

ÖZlem Sardan Sukas

A chemical reactor is implemented on a substrate. The chemical reactor has multiple ducts for transporting a fluid and/or gas during use of the chemical reactor, in which the ducts optionally include pillar structures and at least one connection duct connected between two of the multiple ducts for transporting the fluid and/or gas from one duct to another. In the connection duct, a series of individual pillar structures are positioned behind each other in the longitudinal direction of the connection duct.

Chemical reactors

A microfluidic device for analysing a specimen comprises a loading area for loading the specimen of interest and an analytical column. The loading area is connected on two sides to a first duct and a second duct respectively, both integrated in the microfluidic device. The microfluidic device comprises a first integrated input connected to the first duct to take the specimen into the loading area, a first integrated output connected to the second duct to discharge the rest of the specimen, once it has flown through the loading area, and a second integrated output downstream the analytical column. The first integrated output is arranged for during a first loading period of time being in circuit connected to the first integrated input so as to load the sample into the loading zone of the device while preventing loss of specimen during loading of the sample into the analytical column.

Microfluidic device

A system for imaging particles in a fluid includes a substrate holder for holding a substrate comprising a channel or reservoir for containing the fluid in the substrate, a radiation source for providing irradiation in the substrate and a radiation detection unit for detecting particles in the fluid in the substrate. At least one of the radiation source and the radiation detection unit) are configured to obtain detection in one or more distinct detection sheets in the substrate. The system further comprises an actuator configured for imparting an oscillating mechanical movement of the substrate holder regarding the radiation detection unit and the radiation source, the oscillating mechanical movement being a movement comprising a movement component in a direction perpendicular to the plane wherein the one or more detection sheets are extending.

3D particle imaging

A method for producing a chemical reactor, wherein the chemical reactor comprises one or more effective channels which comprise pillar structures, an input connected to one of the effective channels to allow fluid/gas into the effective channels and an output connected to one of the effective channels to remove at least one component of the liquid/gas. The method comprises obtaining an initial design of the reactor, further introducing into the initial design at least a structured area positioned adjacent to an effective channel of the one or more effective channels located at the edge of the initial design, the structured area not being fluidly connected to one of the effective channels, to obtain a further design and the production of the reactor according to the further design.

Production of chemical reactors

A microfluidic device comprises a microfluidic channel having at least an inlet for receiving a fluid plug or an outlet for removing a fluid plug and a pillar based flow distributor for reorienting the fluid plug in such a way that the long axis of the fluid plug essentially is oriented perpendicular to the walls of the microfluidic channel, as opposed to its original orientation, in which the longer axis is oriented in the longitudinal direction of the narrower inlet channel. The width W of the microfluidic channel is substantially larger than the width w of the inlet or outlet channel. The microfluidic device is adapted for detecting a physical or chemical property of the fluid, the microfluidic device being configured for detecting the property in a detection area positioned across the microfluidic channel in a width direction of the microfluidic channel.

Lateral detection of fluid properties

A method for producing a chemical reactor device based on a fluid flow comprises obtaining a substrate with a fluid channel defined by a channel wall, in which an ordered set of silicon pillar structures is positioned in the fluid channel and electrochemically anodising at least the silicon pillar structures to make the silicon pillar structures porous at least to a certain depth. After the anodising, the substrate and pillar structures are thermally treated, the treatment being carried out at a temperature, with a duration and in an atmosphere such that any silicon oxide layer formed has a thickness of less than 20 nm. The substrate and the pillar structures are further functionalized.

Method for producing chemical reactor

A micro-reactor system for contacting fluids is described. The system comprises a first microfluidic channel structure for guiding a first fluid to at least one output nozzle thus generating a first sub-flow, a second microfluidic channel structure for guiding a second fluid to at least a second output nozzle thus generating a second sub-flow, said first output nozzle being aligned with said second output nozzle and arranged for contacting the first sub-flow and the second sub-flow. The micro-reactor comprises at least a third microfluidic channel structure for at least a third, inert, fluid generating at least a third sub-flow arranged to be positioned adjacent at least the first and/or the second sub-flows so as to act as a wall between said first and/or second sub-flows.

Mixing of fluids

A chromatographic column assembly is described, comprising a channel and a flow inducer. The channel comprises an inlet for receiving a sample liquid and an outlet, and is adapted for separating the sample liquid into components when the sample liquid flows through the channel in an axial direction from the inlet to the outlet. The flow inducer is adapted for controllably inducing, when the sample fluid is flowing through the channel, a motion of the sample liquid in the channel in a plane substantially orthogonal to the axial direction.

High-performance liquid chromatography

A microfluidic device for separating a phase in a specimen has been described. This is based on a microfluidic trapping area, channels connected to it and integrated inputs and outputs connected onto the channels. An additional integrated input is provided which allows the flow in the device to be controlled and which may prevent leaking of the specimen and the phase.

Growing community of inventors

Berchem, Belgium

Wim De Malsche