Janssen R&d Ireland

Janssen Vaccines & Prevention B.v.

Tibotec Pharmaceuticals Ltd.

Wim Bert Griet Schepens

Bart Rudolf Romanie Kesteleyn

Tim Hugo Maria Jonckers

Judith Baumeister

Geerwin Yvonne Paul Haché

Gerben Albert Van 't Klooster

Beate Sabine Hallenberger

Jennifer Chiyomi Sasaki

Pierre Jean-Marie Bernard Raboisson

Bengt Bertil Samuelsson

Christophe Francis Robert Nestor Buyck

Hans Kristian Wallberg

Boerries Brandenburg

Jaroslaw Juraszek

Genadiy Kalayanov

Johannes Wilhelmus J Thuring

Kevin Parkes

Jörg Kurt Wegner

Maria Van Dongen

Joerg Kurt Wegner

The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.

Influenza virus neutralizing peptidomimetic compounds

The present invention relates to compounds of formula (I) that have CYP450 inhibiting properties and are useful as boosting agents when used with HIV treatments. These compounds are represented by formula including the salts and stereoisomeric forms thereof, wherein Ris 5-thiazolyl or 3-pyridinyl; Ris iso-butyl, 2,2-dimethylpropyl; 2-hydroxy-2-methyl-propyl or cyclohexylmethyl; Ris phenyl optionally substituted with one or more halogens, trifluoromethyl, C-alkyl or C-alkoxy wherein optionally two of said alkoxy groups are be linked to each other to form a 5 or 6-membered ring; heteroaryl; Ccycloalkyl optionally substituted with one or more halogens; Calkyl optionally substituted with heteroaryl; &#x2014;O&#x2014;CH&#x2014; (heteroaryl). As boosting agents they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered, or improve the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions comprising these compounds are also provided.

Amide compounds as boosters of antivirals

HIV inhibitors of formula (I) wherein Ris halo, Calkoxy, trifluoromethoxy; Ris a group of formula (A); Ris a group of formula (B); Ris a group of formula (C); n is 0 or 1; A is CH or N; Rand Rare hydrogen, Callyl, halo; Rand Rare Callyl or Calkoxy-Calkyl; Ris Callyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; Ris hydrogen, Calkyl, cyclopropyl, trifluoromethyl, Calkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.

5-amino-4-hydroxypentoyl amides

The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions are also provided.

HIV inhibitory compounds of formula: salts, hydrates, solvates, N-oxides, or stereoisomers thereof, wherein

HIV inhibiting 3,4-dihydro-imidazo[4,5-B]pyridin-5-ones

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Mechelen, Belgium

Wim Bert Griet Schepens