Durect Corporation

Santen Pharmaceutical Co., Ltd.

The United States Government As Represented by the Department of Veterans Affairs

Virginia Commonwealth University

Wilma Tamraz

Jeremy C Wright

John W Gibson

Andrew R Miksztal

Keith Edward Branham

Stefania Sjobeck

John J Leonard

Brooks Boyd

Huey-Ching Su

Sreenivasu Mudumba

Shunlin Ren

Christopher M Rubino

WeiQi Lin

Jin Koung Kim

Komei Okabe

Kazuhito Yamada

Naoki Matsumoto

Min L Lee

Leyuan Xu

Yanxia Ning

Hongwei Wu

Meej Kim

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25&#xb0; C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material

Pharmaceutical compositions comprising an active pharmaceutical ingredient, a high viscosity liquid carrier material, a hydrophobic solvent, and a hydrophilic solvent are disclosed. Also disclosed are methods of manufacturing and using the compositions. The compositions are suitable for use, e.g., as depot formulations.

Depot formulations

Injectable controlled release composition comprising high viscosity liquid carrier

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.

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San Jose, CA, United States of America

Wilma Tamraz