University of California

Ludwig Institute for Cancer Research Limited

Sidney Kimmel Cancer Center

William Wachsman

Wolfgang Klump

Tracy Martin

Michael McClelland

Robert Oden Stuart

Daniel Mercola

Steven Goodison

Linda Wasserman

Jessica Wang-Rodriguez

Igor Klacansky

David Tarin

Charles C Berry

Karen Arden

Among the methods, compositions, combinations and kits provided herein are those for determining gene expression levels in one or more cell types in heterogeneous cell samples, for identifying genes differentially expressed in different cell types, and for detecting a cell type in a sample from a subject. Also provided herein are methods, compositions, combinations and kits for determining gene expression levels in cells corresponding to phenotypes, and for identifying a phenotype of a subject by detecting differentially expressed genes.

Cell-type-specific patterns of gene expression

The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family called small nuclear factors or SNFs. The expression of these compounds are shown to correlate with cell lineage, activation and infection. SNFs and T-cell specific forms of JunB, find particular use in screening assays for agents or lead compounds for agents useful in the diagnosis, prognosis or treatment of disease, particularly HTLV infection. Nucleic acids encoding SNFs, and SNF-specific binding agents find use in diagnosis and as commercial reagents for the biopharmaceutical industry.

Human T-cell leukemia virus transcription modulators and screening assays

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Encinitas, CA, United States of America

William Wachsman