Eli Lilly and Company

Indiana University

Assembly Biosciences, Inc.

Other

William W Turner

Hans Maag

Lee Daniel Arnold

Mark G Bures

Samson Francis

Jeffrey S Nissen

Stephen A Hitchcock

Manuel Debono

Michael J Rodriguez

Peter S Borromeo

Jennifer Rebecca Allen

Leping Li

Simon Nicolas Haydar

James Andrew Jamison

Bin Liu

Frederick J Burkhardt

Michael S Van Nieuwenhze

Gerald Floyd Smith

Joseph L Witztum

Adam Zlotnick

Jack B Campbell

Mark J Zweifel

Lichun Li

Roopa Rai

Venkatraghaven Vasudevan

Lisa M LaGrandeur

Karsten Hartvigsen

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Hepatitis b core protein modulators

Hepatitis B core protein modulators

Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.

Fluorescent-HAP: a diagnostic stain for HBV cores in cells

The present invention provides a peptide-phospholipid conjugate of Formula 1: wherein: X is selected from the group consisting of &#x2014;CRR&#x2014;, &#x2014;R&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, and S(R)&#x2014;; Y is selected from the group consisting of a bond, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, amino, ether, cycloamino, cycloether, aryl heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl; Z is a peptide comprising 1 to 50 amino acids; Rand Reach independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, amino, ether, cycloamino, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl; and Ris selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, amino, ether, cycloamino, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl.

Peptide-phospholipid conjugates

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor 

Muscarinic agonists

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor 

Indane derivates as muscarinic receptor agonists

Provided are compounds of the formula (1): ##STR1## wherein R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;

Cyclic peptide antifungal agents

Cyclic peptide antifungal agents and process for preparation thereof

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I ##STR1## where: R', R', R'', R.sup.x1, R.sup.x2, R.sup.y1, R.sup.y2, R.sup.y3, R.sup.y4, and R.sup.0 are as defined above; and

Cyclic peptide antifungal agents and methods of making and using

A device and method for continuously monitoring the availability of an external electric power supply into a recreational vehicle such as a motor home, a boat and the like and controlling the operation of an onboard engine powered generator to serve as an alternate source of electric power for the recreational vehicle. After a predetermined initial time delay following external power source failure, the device activates the cranking motor for a predetermined cranking time period to attempt to start the engine. After another predetermined waiting time period, the cranking motor will be reactivated for the cranking time period if the engine has failed to start and supply electric power to the recreational vehicle. As soon as external electric power is restored, the engine is automatically shut off by the device.

Automatic generator start up and shut off device

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein R', R', R.sup.x1, R.sup.x2, R.sup.y1 -R.sup.y4, R.sup.z1, R.sup.z2, a, b, c, d, e, R.sup.0, R.sup.1 and R.sup.2 are defined as in the specification.

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I: ##STR1## wherein: R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;

Cyclic peptide antifungal Agents

Substituted propanamines having anticoagulant or antifungal activity are disclosed. Also disclosed are methods of use involving the substituted propanamines as well as pharmaceutical compositions containing them.

Growing community of inventors

Bloomington, IN, United States of America

William W Turner