Eli Lilly and Company

William W Hargrove

Dale C Harris

Charles R Sperry

Michael J Akers

Nelson R Easton

An apparatus for connecting a vial into the delivery tube of an intravenous administration set, the set including a container of fluid connected to one end of a delivery tube with the other end of the delivery tube adapted for insertion into the patient. The apparatus includes a penetrating spike penetrating an end of the vial which provides two pathways into the interior of the vial with two sections of the delivery tube connected to the two pathways of the penetrating spike. The apparatus also includes a frame for maintaining the two sections of the delivery tube adjacent to each other and clamp for releasably closing the adjacent sections of the delivery tube to temporarily prevent flow of fluid through the penetrating spike.

Vacuum vial infusion system

Valved adaptors are disclosed permitting the introduction of a drug-containing vial in the delivery tube of an I.V. administration set. The adaptors have a three position operation characterized by a bypass mode, a dilution mode, and a delivery mode, the adaptors being manually changed from mode to mode. The disclosed adaptors include gravity operated valves, reciprocating spool valves, and rotating spool valves, each including a spike to penetrate the stopper of a vial and a vent to permit air to escape the vial as liquid is introduced to dilute the vial contents.

Controlled release infusion system

The system of this invention provides a method and apparatus for the sterile intravenous administration of dry medicine. Such a system can include standard IV set components such as a source of liquid, means to inject liquid into a human vein, means forming a passageway between the source of liquid and said injection means, a valve to control the flow of liquid through the passageway, and a cartridge-like dry medicine package adapted for use with the system. Such a package can include conduit means adapted to perforate and communicate with the passageway, means forming a cell for dry, particulate medicine with portions forming a liquid-pervious barrier to the dry medicine and an air vent with an air-pervious, liquid barrier. The perforating conduit means is in communication with the liquid-pervious barrier portion of the cell so that, upon perforation of the passageway means by the perforating conduit means below the source of liquid, the cell fills with liquid, the medicine is placed in solution in the liquid, and the medicine solution flows into the vein. Dry medicine can, for example, be administered intravenously in liquid solution in a variety of dosages and at a variety of rates without resort to a pharmacy by enclosing it in such a sterile package adapted for addition to an IV system at a patient's bedside.

Intravenous administration system for dry medicine

4,4-Spiro-oxazolinium halides, named systematically as 1-oxo-3-azaspiro[4.4]nonane hydrohalides or 1-oxo-3-azaspiro[4.5]decane hydrohalides, and 4,4-dimethyl oxazolinium halides, useful as intermediates in the synthesis of hypotensive azetidinones.

4,4-Substituted-oxazolinium halides

A novel process for preparing oxazolinium salts useful in the preparation of .alpha.'-halo .alpha.,.alpha.-disubstituted .alpha.-amino ketones.

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Indianapolis, IN, United States of America

William W Hargrove