The Brigham and Women's Hospital, Inc.

William W Chin

James K Liao

Mitchell A Lazar

Richard A Hodin

This invention provides new methods and compounds for controlling the intracellular and physiological effects of steroid hormones, including but not limited to estrogen, through modulation of the interaction of such hormone receptors with phosphatidylinositol-3 kinase. Compounds and methods for controlling the activation of endotbelial nitric oxide synthase are also disclosed.

Methods of identifying a compound which modulates the non-transcriptional non-map-kinase induced effects of steroid hormones

The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA.alpha.-1, erbaA.alpha.-2 and erbA.beta.-1. The gene encoding PSTHR, erbA.beta.-2, is partially homologous to the erbA.beta.-1. However, PSTHR differs from the product of erbA.beta.-1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.

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Wellesley, MA, United States of America

William W Chin