Pfizer Corporation

William W Armstrong

Charles E Moppett

Wendell W Windisch

Saurabhkumar J Desai

Aqueous parenteral solutions of from about 10 to 20% w/v of sulfamethoxazole or sulfadoxine and about 3 to 5% w/v of trimethoprim in from about 60 to 80% w/v of 2-pyrrolidone are disclosed.

Sulfonamide compositions

The 1:2 N,N'-dibenzylethylenediamine, the N-benzyl-2-phenylethylamine and the dibenzylamine salts of penicillanic acid 1,1-dioxide, a well-known betalactamase inhibitor, are sparingly soluble in water. Accordingly they are valuable as slow release (depot) forms of penicillanic acid 1,1-dioxide, particularly for use in conjunction with slow release (depot) forms of penicillin and cephalosporin antibiotics, in the chemotherapy of bacterial infections in mammals.

Sparingly water-soluble salts of penicillanic acid 1,1-dioxide

Aqueous parenteral solutions of from about 10 to 20% w/v of sulfamethoxazole or sulfadoxine and about 3 to 5% w/v of trimethoprim in from 60 to 80% w/v of 2-pyrrolidone are disclosed.

Pharmaceutical compositions containing magnesium-calcium-oxytetracycline mixed chelates in aqueous 2-pyrrolidone solution are disclosed.

Oxytetracycline compositions

Aqueous solutions of oxytetracycline, doxycycline or chlortetracycline in caprolactam or 2-piperidone are disclosed.

Tetracycline antibiotic compositions

Aqueous solutions of doxycycline or salts thereof, a pharmaceutically acceptable soluble magnesium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 3 to 7.5 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.

Doxycycline compositions

Aqueous solutions of chlortetracycline or salts thereof, a pharmaceutically acceptable calcium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 8 to 10 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.

Chlortetracycline compositions

Aqueous solutions of tetracycline or salts thereof, a pharmaceutically acceptable soluble magnesium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 7.5 to 9.5 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.

Tetracycline compositions

Oxytetracycline aqueous solutions containing 2-pyrrolidone as a co-solvent suitable for pharmaceutical use and especially useful for either oral, topical or parenteral administration are disclosed.

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Mill Neck, NY, United States of America

William W Armstrong