Juul Labs, Inc.

Novartis Ag

Philip Morris Products S.a.

Nektar Therapeutics

Other

Novartis Pharma Ag

Pentagon Technologies Group, Inc.

William W Alston

James Monsees

Adam Bowen

Joshua A Kurzman

Carlos A Schuler

Alex Stenzler

Steve Han

Andrew Clark

Steven Ellis

Noe Zamel

Arthur Slutsky

Paul R Vieira

Ian Garcia-Doty

John Paul Palmer-Felgate

George S Axford

Nagaraja P Rao

Mark Glusker

Bradley J Ingebrethsen

David Selby Maltz

Kevin Russert Walsh

Jonathan Wilkins

Keith Ung

Jacob R Davis

Timothy J Watson

Joseph S Wilinski, Jr

Willard R Foss

Mark Postich

Andrew J Pappas

Neeraj Pakala

Adrian Edward Smith

Sarvajna Kumar Dwivedi

Kevin S Nason

Steve Paboojian

Dennis Rasmussen

Derrick Tuttle

David Browne

Don Lutz

Guy V Tucker

Stephen Smeulders

Brian R S Ward

Aneesh Bakshi

Saravajna K Dwivedi

An apparatus includes a housing including a power source; a reservoir including an inlet, an outlet, and configured to contain vaporizable material and couple to the housing; and a PTCR heating element configured to electrically couple to the power source and heat the vaporizable material to form an aerosol. The PTCR heating element includes an electrical resistivity that varies based on temperature. The electrical resistivity includes an electrical resistivity transition zone including an increase in electrical resistivity over a temperature range such that, when the PTCR heating element is heated to a first temperature within the transition zone, current flow from the power source is reduced to a level that limits further temperature increases of the PTCR heating element. Related apparatus, systems, techniques, and articles are also described.

Vaporizer including positive temperature coefficient of resistivity (PTCR) heating element

Various embodiments of a vaporization device are described that include one or more features, such as for generating a combined inhalable aerosol. In some embodiments, the vaporization device can include one or more heaters that are configured to heat one or more vaporizable materials. Various embodiments of heating elements and heating systems for use in vaporization devices are also described.

Vaporizer device with more than one heating element

A vaporizer device includes a housing including an air inlet, a heating element within the housing and a heat exchanger. The heating element includes a nonlinear positive temperature coefficient of resistance material. The heat exchanger is thermally coupled to the heating element and arranged to receive airflow from the air inlet. The heat exchanger is configured to transfer heat between the heating element and the airflow to produce a heated airflow. The heated airflow exiting the heat exchanger is configured to vaporize a vaporizable material. Related apparatus, systems, techniques and articles are also described.

Vaporizer including positive temperature coefficient of resistivity heater

A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.

Dry powder inhalers with partial dosage delivery

A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.

Dry powder inhaler and method of use

Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.

Dual resistance dry powder inhaler

A device for counting particles on a sample surface includes a scanner probe having a first opening for receiving particles from a sample surface and one or more second openings, a particle detector for detecting particles passed there-through, a modulator for modulating air flowing there-through, a pump for producing a first airstream flowing from the first opening and through the particle detector, and for producing a second airstream flowing through the modulator and to the one or more second openings, and control circuitry for controlling the modulator to modulate an amplitude of the second airstream.

Modulated air surface particle detector

Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing, mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices

Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

An aerosol introducer is provided for introducing an aerosolized pharmaceutical formulation into a ventilator circuit. The ventilator circuit comprises an endotracheal tube, an inhalation line extending from a ventilator, and an exhalation line extending from the ventilator. The aerosol introducer comprises a first end connectable to the inhalation line and the exhalation line; a second end connectable to the endotracheal tube; a first channel extending from the first end to the second end; a second channel extending from the first end to the second end; an inlet in the first channel, the inlet being adapted to receive an aerosolized pharmaceutical formulation; and a valving mechanism comprising one or more valves that reduce the loss of aerosolized pharmaceutical formulation to the exhalation line.

Introducing aerosol into a ventilator

An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

Increased dosage metered dose inhaler

An aerosolization device comprises a housing, a container comprising a reservoir storing a pharmaceutical formulation which comprises a propellant, and a metering valve. The metering valve is in communication with the reservoir and is moveable into the container to an actuated position where a predetermined amount of the pharmaceutical formulation is released. A contact member is provided in the housing. In one version, the contact member is moveable between a first position and a second position to allow for selective actuation of the metering valve. In another version, the contact member's configuration may be changed to allow for selective actuation of the metering valve.

Metered dose inhaler with lockout

An aerosolization apparatus comprises a body defining an inlet opening, an outlet opening, and an aerosolization chamber between the inlet opening and the outlet opening. The aerosolization chamber is adapted to receive an elongated receptacle, such as a capsule, containing a pharmaceutical formulation. The elongated receptacle rotates end-over-end about an axis substantially orthogonal to an axis passing through the outlet opening when air or gas flows through the body. In another version, the elongated receptacle rotates end-over-end about an axis substantially orthogonal to an inhalation direction.

Aerosolization apparatus with rotating capsule

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San Jose, CA, United States of America

William W Alston