Optical Sensors, Inc.

Teikoku Pharma Usa, Inc.

Verde Environmental Technologies, Inc.

William V Fowler

Laurie E Lynch

Carter R Anderson

Laura J Bauer

Lynn M Kimball

Kevin R Seifert

Alan Olstein

Jo Pritchard

Jonathan Kalla

Debra K Johnson

Russell L Morris

Robert Cohen

Clayton Anderson

Wylie I Lee

Jason E Alderete

Compositions comprising a blister pack, a container dimensioned to hold the blister pack and a pharmacological agent activity mitigation component are provided. Also provided are methods of making and using the compositions.

Blister pack disposal system

An integrated iontophoresis skin-worn patch and method for delivering a therapeutically effective amount of a corticosteroid drug compound in a systemically-safe and skin-safe manner for site-specific treatment of inflammation pain is disclosed.

Transdermal methods and systems for the delivery of corticosteroid compounds

Devices for use in the disposal of pharmaceutical compositions are provided. Aspects of the devices include: a support having a surface; an activated carbon layer present on the surface; and an adhesive for stably associating a pharmaceutical composition with the activated carbon layer upon application of the pharmaceutical composition to the activated carbon layer. Also provided are methods of using the devices and kits containing the devices.

Transdermal patch disposal system

General medication disposal systems are provided. Aspects of the systems include devices having a sealable container dimensioned to accommodate a pharmaceutical composition; and an amount of an inactivating substance, e.g., granulated or pelletized activated carbon, present inside of the sealable container. Aspects of the invention further include methods of making and using the systems, as well as kits comprising the devices of the system.

General medication disposal system

The present invention discloses novel polymer compositions comprising cellulose acrylamide, acrylamide and/or a fluorescent indicator species, and membranes made with these compositions. Optical pH sensors for monitoring the pH in a fluid sample, and methods for making such pH sensors are also disclosed. The pH sensors have reduced sensitivity to sample components that can interfere with pH measurements.

Optical sensor membranes having improved barrier properties

A method for making a optical sensor for measuring the pH of a fluid includes the steps of applying a solution containing (a) a cellulose acrylamide, (b) an acrylamide, and (c) a copolymerizable monomeric fluorescent indicator species to the distal end of an optical fiber and polymerizing the solution to form a pH sensor means.

Method for making an optical sensor having improved barrier properties

A method for making a fiber optic sensor includes the steps of applying an adhesive composition to the distal end of an optical fiber, and applying a solution containing a copolymer of (a) a cellulose acrylamide, (b) an acrylamide, and (c) a copolymerizable monomeric fluorescent indicator species thereto to form a sensing layer.

Membranes and optical sensors made therewith having improved barrier

An optical method for obtaining hematocrit values of blood uses the light transmittance properties of blood as a means of acquiring information about the blood sample. An algorithm is used to calculate the hematocrit value based on the absorbance spectra obtained at wavelengths of approximately 500 nm and 800 nm. These absorbance wavelengths are selected for their insensitivity to the oxygen saturation level of hemoglobin. Additionally, the algorithm has demonstrated insensitivity to plasma and other blood constituent scattering effects.

Optical measurement of blood hematocrit incorporating a self-calibration

A method is provided for manufacturing a fiber optic sensor for detecting or measuring a parameter of interest in a sample fluid, including pH, concentration of dissolved gases such as O.sub.2 or CO.sub.2, and the like. The sensing chemistry is affixed to the distal end of an elongated optical fiber by way of an adhesive layer typically comprised of an acrylic adhesive composition. Novel optical sensors, fabricated using the aforementioned method, are provided as well.

Fiber optic sensor

A method is provided-for manufacturing a fiber optic sensor for detecting or measuring a parameter of interest in a sample fluid, including pH, concentration of dissolved gases such as O.sub.2 or CO.sub.2, and the like. The sensing chemistry is affixed to the distal end of an elongated optical fiber by way of an adhesive layer typically comprised of an acrylic adhesive composition. Novel optical sensors, fabricated using the aforementioned method, are provided as well.

Method for manufacturing fiber optic sensors

An optical sensor is provided for measuring the pH of a fluid sample. The sensor is formulated using a fluorescent polymer composition comprising a copolymer of a water-dispersable, polyether-containing urethane olefin precursor and a fluorescent monomer species, wherein the ratio of precursor and fluorescent monomer species is such that a predetermined apparent pKa is provided. The sensor is prepared by coating the distal end of an optical waveguide with the fluorescent polymer composition, and curing the copolymer contained in the composition, e.g., by exposure to radiation of a suitable wavelength.

Growing community of inventors

Minneapolis, MN, United States of America

William V Fowler