Abbvie Inc.

William T Riordan

Sanjay R Chemburkar

Michael J Abrahamson

Rajarathnam E Reddy

David R Hill

Jianzhang Mei

Timothy B Towne

Angelica B Kielbus

Gareth J Brown

Stefan Mix

Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

Enzymatic process for the preparation of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropanecarboxylic acid

Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.

Variant polypeptides capable of aminating aliphatic alpha keto acids

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Libertyville, IL, United States of America

William T Riordan