Abbott Laboratories Corporation

Spectrum Pharmaceuticals, Inc.

Tekmira Pharmaceuticals Corporation

Acrotech Biopharma Inc.

Arbutus Biopharma Corporation

William T Monte

Aline C Lindbeck

Xiu Chun Wang

Robert M Abra

Yuanpeng Zhang

Jufang Barkalow

Russell C Klix

Thomas Philip Weber

Christopher James Barbosa

Annette A Johnston

Laurie Scaggs

Bing Luo

Robert Malcolm Abra

Disclosed herein are various compositions comprising neoplastic formulations and their methods of use.

Ready-to-use formulation for Vincristine Sulfate Liposome Injection

Improved methods for efficiently constituting liposome encapsulated vincristine for intravenous injection (VSLI) with reduced risk of operational errors and contamination are disclosed.

Method for the preparation of liposome encapsulated vincristine for therapeutic use

The present invention relates to a process for preparing a cross-linked pollyallylamine hydrochloride. The process involves mixing polyallylamine hydrochloride, water, a hydroxide or alkoxide, and a water-miscible organic solvent or co-solvents, to a reaction mixture and adding a cross-linking agent to the reaction mixture to form a cross-linked polyallylamine.

Process for producing cross-linked polyallylamine hydrochloride

A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.

Process of protecting a 1,2-aminoalcohol for reductive amination coupling

A process for the crystallization of an iron-dextran complex in readily-filterable form comprising adding slowly, with stirring, an acidified aqueous iron-dextran solution to a vessel containing a water miscible organic solvent such as methanol, as well as crystalline iron-dextran complexes so prepared.

Process for making crystalline iron dextran

The present invention provides a process for the preparation of BPD 1,4-diene diester A-ring comprising reacting hematoporphyrin IX dimethyl ester with dimethyl acetylenedicarboxylate followed by purification of the product by a series of fractional crystallizations.

Process for the preparation of a protoporphyrin

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Lincolnshire, IL, United States of America

William T Monte