Arrow International Limited

Semprus Biosciences Corporation

Semprus Biociences Corporation

William Shannan O'Shaughnessey

Chad Cori Huval

Zheng Zhang

Christopher R Loose

Jun Li

Michael A Bouchard

Trevor Squier

Michael Hencke

Michael Bouchard

Chad Huval

Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

Layered non-fouling, antimicrobial antithrombogenic coatings

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Boston, MA, United States of America

William Shannan O'Shaughnessey