Wyeth

Abbott Laboratories Corporation

William Sanders

Amedeo A Failli

Eugene John Trybulski

Douglas M Kalvin

Rolf Wagner

Zhenkun Ma

Hong Yong

Michael D Tufano

Christopher E Motter

Curt S Cooper

Jay Scott Shumsky

David D Anderson

Moshe Weitzberg

Mira Hinman

Teresa A Rosenberg

Bruce A Beutel

Yu-Gui Gu

Linda M Lynch

Peter Dandliker

Caroline David

Gary T Wang

Anil Vasudevan

George S Sheppard

David M Barnes

Todd M Hansen

Richard F Clark

Robert A Mantei

Thomas Joseph Caggiano

Megumi Kawai

Jieyi Wang

Kevin Anthony Memoli

Lawrence Kolaczkowski

Jack Henkin

Joseph Peter Sabatucci

Jason S Tedrow

Scott A Erickson

Steve D Fidanze

Daniel P Larson

Todd D Bosse

Nwe Y BaMaung

Tianyuan Zhang

Fabio Palazzo

Kenneth M Comess

Ki H Kim

Chang Hoon Park

David C Park

Tamara Rehm

Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

Antibacterial compounds

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Sulfonamides having antiangiogenic and anticancer activity

The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists

The present invention provides novel tricyclic diazepine compounds and methods and pharmaceutical compositions utilizing them for the treating or preventing disorders including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, congestive heart failure or for inducing temporary delay of urination, and in conditions with increased vascular resistance and coronary vasoconstriction; and for the treating or preventing disorders remedied or alleviated by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea, endometritis, and for suppressing labor at term prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators

The present invention provides substituted 10,11-Dihydro-5H-benzo[e]-pyrrolo[1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals.

Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists

The present invention provides novel tricyclic pyridyl carboxamides as well as methods and pharmaceutical compositions utilizing them compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists

This invention provides novel substituted tricyclic carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea and endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists

Growing community of inventors

Fox Lake, IL, United States of America

William Sanders