Osteogenex, Inc.

Depuy Spine, Inc.

Ossifi Inc.

Etzem, Inc.

William S Rosenberg

Debra Ellies

Thomas V Doherty

Mark C Boomer

Bryan S Jones

Spinal implants, spinal rod approximators for seating a stabilizing rod in a rod-receiving portion of a spinal implant, and methods for using the same are provided. In one embodiment, a spinal rod approximator is provided including an elongate member having a grasping member formed on a distal end thereof, and a rod pusher member slidably mated to or mounted on the elongate member. The grasping member is effective to grasp a portion of a spinal implant, and the pusher member is effective to grasp and engage a stabilizing rod and push the rod into a rod-receiving portion of the spinal implant being grasped by the grasping member.

Spinal rod approximator

The present invention provides a method of reducing body weight in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I: In Formula I, Ris H, Calkyl, or Calkyl-aryl. Each of Rand Rof Formula I are independently H, halogen, Calkyl, Chaloalkyl, Calkenyl, Calkynyl, Chaloalkoxy, &#x2014;OR, &#x2014;SR, &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NRR, &#x2014;NRR, Calkyl-NRR, &#x2014;N(R)C(O)R, &#x2014;N(R)C(O)OR, &#x2014;N(R)C(O)NRR, &#x2014;OP(O)(OR), &#x2014;S(O)OR, &#x2014;S(O)NRR, &#x2014;CN, &#x2014;NO, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each of Rand Rof Formula I are independently H, Calkyl, Cheteroalkyl or Calkyl-aryl. Rof Formula I is absent, Calkyl or N-oxide. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of obesity and disorders related to obesity and higher than recommended percentage body fat, such as type II diabetes.

Ellipticine compounds for treating obesity

The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The present invention also provides methods for the treatment of renal disease and cancer.

Boldline compounds for promoting bone growth

The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.

Vinpocetine and eburnamonine derivatives for promoting bone growth, treating renal damage and cancer, and devices thereof

Boldine compounds for promoting bone growth

The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each Rand Ris H, halogen, Calkyl, Calkoxy, Chaloalkyl, Calkenyl, Calkynyl, Chaloalkoxy, &#x2014;OR, &#x2014;NRR, &#x2014;SR, &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NRR, &#x2014;N(R)C(O)R, &#x2014;N(R)C(O)OR, &#x2014;N(R)C(O)NRR, &#x2014;OP(O)(OR), &#x2014;S(O)OR, &#x2014;S(O)NRR, &#x2014;CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each Rand Ris H or Calkyl. X is O, S or NR. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.

Growing community of inventors

Overland Park, KS, United States of America

William S Rosenberg