Northwestern University

Northeastern University

William S Hancock

Barry L Karger

Andras Guttman

Laszlo A Takacs

M K Disni R Dayarathna

Manuel Duval

Marina Hincapie

Patrick Berna

MK Disni R Dayarathna

Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods.

Biomarkers for diabetes, obesity, and/or hypertension

A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of the classical biomarker discovery and development process. The invention provides a platform for the rapid, high-throughput production, isolation and characterization of, e.g., disease specific biomarkers together with highly specific monoclonal antibodies. The method of the invention has a variety of applications such as, but not limited to, drug testing, biohazard applications, ecological applications, physiological applications and/or pathology screening applications. The method of the invention is also capable of being performed or used as or with a high-throughput screening process or system of the invention.

Monoclonal antibody based biomarker discovery and development platform

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Brookline, MA, United States of America

William S Hancock