Ucbbiopharma Srl

Ucb Pharma, S.a.

Ucb Biopharma Sprl

William Ross Pitt

Graham John Warrellow

Timothy John Norman

John Robert Porter

Andrew Sharpe

Stephen Edward Rapecki

Boris Kroeplien

Daniel John Lightwood

Christopher Lowe

Alastair Lawson

James Philip O'Connell

Mark Daniel Calmiano

Stephen Robert Mack

Tracy Lynn Arakaki

Marianna Dilani Richard

Laura Jane Tait

Natasha Kinsella

David Andreas Schubert

Alex Buntin Burgin

Rikki Peter Alexander

Daniel Christopher Brookings

Alan Findlay Haughan

Julien Alistair Brown

Roland W Bürli

Jag Paul Heer

Matthew Duncan Selby

Judi Charlotte Neuss

Stephen Brand

Verity Margaret Sabin

Stuart Bailey

Richard Jeremy Franklin

Daniel Rees Allen

George Martin Buckley

Alistair James Henry

Richard John Davenport

Andrew James Ratcliffe

Rebecca Jayne Munro

James Madden

Oliver Philps

Christopher James Lock

Giancarlo Trani

Gregory William Haslett

Zhaoning Zhu

Selvaratnam Suganthan

Rickki Lee Connelly

Konstantinos Rampalakos

Pfrafulkumar Tulshibhai Chovatia

Rebecca Jayne Wootton

John Richard Davenport

Sophie Caroline Williams

Zeshan Yousuf

Roland BÜRLI

James Philip O'CONNELL

Thiophene derivatives of formula (I) and a pharmaceutically acceptable salt thereof are provided. These compounds have utility for the treatment or prevention of disorders caused by IgE, such as allergy, type 1 hypersensitivity or familiar sinus inflammation.

Thiophene derivatives for the treatment of disorders caused by IgE

A new, stable trimeric TNF&#x3b1; structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF&#x3b1;/TNFR1 interaction. Membrane-bound TNF&#x3b1; is not affected in its ability to signal through TNFR2, and thus the new structure of TNF&#x3b1; may be used in therapies which do not significantly raise the risk of infection or malignancy.

Method of identifying potential inhibitors of APO TNF&#x3b1; trimers

Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers

A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions, said substituted derivatives having the general formula 

Quinoxaline and quinoline derivatives as kinase inhibitors

A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Fused thiophene derivatives as kinase inhibitors

Growing community of inventors

Slough, United Kingdom

William Ross Pitt